帕金森病抑郁状态的发生率及相关因素研究

目的研究帕金森病(PD)患者抑郁症状的发生率及其相关影响因素。方法采用抑郁自评量表(self-rating depressionscale,SDS)、汉密顿抑郁量表(Hamilton depression scale,HAMD)对117例帕金森病患者进行评定及诊断,统计分析抑郁的发生情况及严重程度和相关影响因素,并对HAMD进行量表因子分析。结果PD患者抑郁的发生率为43.6%,轻度抑郁占88.2%,单因素分析结果显示:经济状况差、病程较长、H-Y分期和Webster评分高者易出现抑郁。经Logistic回归分析发现抑郁仅与病情有密切关系(Webster评分分级有统计学意义)。根据对HAMD量表各因子的分析,抑郁组患者在认知障碍、迟缓、躯体焦虑、睡眠障碍等方面比非抑郁组得分明显增高(P≤0.001),在体质量减轻方面差异不大。结论PD患者有较高的抑郁发生率,与PD病程、病情分期密切相关。

The Study on Incidence of Depression and Correlated Factors in Patients with Parkinson's Disease

Objective To determine the incidence of depression and correlated factors in Parkinson's patients.Methods 117 Parkinson's patients were diagnosed and assessed using Self-rating Depression Scale(SDS) and Hamilton Depression Rating Scale(HAMD).The incidence,disease severity and correlated factors of depression were statistically analyzed,and a factor analysis was carried out on HAMD.Results The incidence of depression in Parkinson's patients was 43.6%,of which 88.2% were mild depression.Univariate analysis revealed that a high frequency of depression occurred in patients with bad economic status,long Parkinson's disease(PD) duration,high H&;Y stage and Webster score.Depression was found to be only significantly correlated to disease status(the comparisons of Webster score had statistically significance) by means of Logistic regression analysis.According to each factor analysis of HAMD,the scores of cognitive impairment,tardiness,body anxiety and sleep disturbances of the patients with depressive syndromes were higher than that of non-depression patients(P≤0.001).No difference was noted with body weight loss.Conclusion PD patients have a high susceptibility to depression,and duration of PD and H&;Y stage appear to be the strongest predictor of depression.