电针家兔“百会穴”对内生致热原性发热和脑脊液cAMP含量的影响

为了探讨cAMP在电针发热家兔“百会穴”降热效应中的作用,作者选用封闭群大耳白家兔108只,分五组进行实验。实验结果表明:(一)电针发热家兔“百会穴”后,明显降低发热反应和脑脊液cAMP含量增加;(二)电针封闭发热家兔“百会穴”和发热家免“非穴位”后,显示明显的发热反应和脑脊液cAMP含量显著增加;(三)单纯封闭发热家兔“百会穴”,对发热反应和脑脊液cAMP含量增加均无影响。因此,作者推论:电针发热家免“百会穴”抑制发热效应的机理,很可能是和电针“百会穴”中的局部敏感组织(如游离神经末梢)所感受,通过某种方式传入脑内,在脑内又以某种方式抑制cAMP的增多有关,从而抑制调定点上移和出现发热抑制效应。

Observation on fever response of leukocytic pyrogen fever and change of cAMP content in cerebrospinal fluid during electric needling "Baihui" point in febrile rabbits

In order to analyze the mechanism of febrifugal effect of electric needling "Baihui (Hundreds Converge)" point of febrile rabbits, 108 rabbits were divided into 5 groups, serveing as experimental animals. The results obtained showed: 1. In febrile rabbits induced by monoeytic pyrogen, electric needling "Bai hui" points has significant febrifugal effect, i. e. inhibiting the rise of body temperature, in the meantime the cAMP content rose in c. s. f. was markedly inhibited. 2. On febrile rabbits, electric needling blocking "Bai hui" point and Non-acupoint exhibited no marked febrifugal effect, i. e. showing apparently fever response, and at the same time cAMP contents in c. s. f. was strikingly increased. 3. Blocking of "Bai hui" point itself did not produce any effect on pyrogen-induced fever and cAMP content increased.The author inferred that the mechanism of inhibitory effect of electric needling "Bai hui" points in febrile rabbits might be closele assocated with feeling of local sensible tissue (e. g. free nerve endings) in "Bai hui" point, and with producing nerve impuls which transmitted through some mode to brain. As a result, increased cAMP was inhibited and setpoint to move up was inhibited.