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口腔癌凋亡相关基因bcl-2、bax表达的初步研究
引用本文:陈江,温玉明,李龙江,王昌美. 口腔癌凋亡相关基因bcl-2、bax表达的初步研究[J]. 福建医科大学学报, 2001, 35(1): 21-23,F003
作者姓名:陈江  温玉明  李龙江  王昌美
作者单位:1. 福建医科大学附属口腔医院,
2. 华西医科大学口腔医学院,
摘    要:
目的 探讨凋亡相关基因bcl-2及bax基因在口腔癌的表达情况。方法 60例口腔癌的组织切片标本。bcl-2单隆抗体,bax多克隆抗体,SP免疫组织化学染法,结果 60例,bcl-2阳性率为68.33%;bax阳性36.67%。颈淋巴结转移组的阳性率为38.71%,低分化组为17.86%,高中分化组与低化组差异有显著性高分化组的bax阳性率为60%,中分化组为41.67%,低分化组为17.86%,高中分化组与低分化组差异有显著性(P<0.05)。结论 bcl-2和bax在分化较好的早期肿瘤细胞中表达较多,随着分化程度的降低,bcl-2及bax表达率也降低。

关 键 词:口腔肿瘤 bcl-2基因 bax基因 细胞凋亡 口腔癌
文章编号:1000-2235(2001)01-0021-03

Expression of Cyto-apoptosis Related Gene Bcl-2 and Bax in Oral Sequmous Cell Carcinoma
CHEN Jiang+,WEN Yu|ming+,LI Long|jiang+,et al. Expression of Cyto-apoptosis Related Gene Bcl-2 and Bax in Oral Sequmous Cell Carcinoma[J]. Journal of Fujian Medical University, 2001, 35(1): 21-23,F003
Authors:CHEN Jiang+  WEN Yu|ming+  LI Long|jiang+  et al
Affiliation:CHEN Jiang+1,WEN Yu|ming+2,LI Long|jiang+2,et al
Abstract:
Objective To explore the expression of bcl 2 and bax in 60 cases of oral sequmous cell carcinoma(SCC). Methods Detection of bcl 2 and bax were used by immunohistochemical SP method. Results Among 60 cases of oral SCC, detection rate of bcl 2 positive cells was 68 33%, which was correlated with pathological grading, and Tumor, Nodes and Metastasis(TNM) classification, but not with cervical lymphatic metastasis(CLM). The detection rate of bax gene was 36 67%, which was related to SCC differentiation, and had no relation with TNM,CLM. Conclution The expression of bcl 2 and bax gene may contribute to oral sequmous cell carcinoma differentiation, bcl 2 being one of the effective factors in oral SCC growth.
Keywords:oral carcinoma  bcl 2 gene  bax gene  apoptosis
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