急性白血病患者口腔感染直接经济损失分析

目的了解急性白血病（AL）患者口腔感染所致的直接经济损失。方法对2011年1月—2013年12月山东省某三级甲等医院血液病房AL口腔感染患者进行调查，采用病例对照的方法进行1︰1配对，比较口腔感染组（病例组）与未感染组（对照组）AL患者的住院费用及住院日数等情况。结果共监测AL患者994例，发生医院感染277例，其中口腔感染17例（5.56%）。病例组患者住院费用中位数为37 327元，对照组为13 176元，病例组患者总住院费用是对照组的2.83倍，差异具有统计学意义（Z=-3.621，P＜0.001）。病例组各项住院费用均高于对照组，住院费用增加最多的是西药费、输血费、化验费和治疗费。病例组住院日数中位数为17 d，对照组为11 d，经秩和检验，两组患者住院日数中位数比较，差异具有统计学意义（Z=-3.627，P＜0.001）。结论AL患者发生口腔感染后导致住院费用增加，住院日数延长，增加了患者的经济负担。

Direct economic loss due to oral infection in acute leukemia patients

ObjectiveTo investigate the direct economic loss caused by oral infection in patients with acute leukemia. MethodsAcute leukemia patients with oral infection in a tertiary first class hospital in Shandong Province between January 2011 and December 2013 were investigated, the 1:1 matched case control method was used for comparing hospitalization expense and length of hospital stay between oral infected (case group) and uninfected patients(control group). ResultsA total of 994 patients with acute leukemia were monitored, 277 had healthcare associated infection, 17 (5.56%）of whom were with oral infection. The median hospitalization expense of patients in case group and control group was￥37 327 and￥13 176 respectively, the total hospitalization expense of patients in case group was 2.83 times more than control group, difference was statistically significant （Z=-3.621，P＜0.001). Each hospitalization expense of case group was higher than control group, especially expense for medicine, blood transfusion, laboratory examination, and therapy. The median length of hospital stay in case group and control group were 17 days and 11 days respectively, rank sum test showed that difference in median length of hospital stay between two groups was statistically significant (Z=-3.627, P< 0.001). ConclusionAcute leukemia patients with oral infection have increased hospitalization expense, prolonged length of hospital stay, and increased the financial burden.