失代偿肝硬化患者纤维蛋白原的变化及临床意义

目的探讨纤维蛋白原（Fbg）在失代偿肝硬化患者血浆的变化情况及临床意义。方法以蕲蛇酶水解Fbg，用计算机自动检测系统测定患者血浆中纤维蛋白单体聚合反应速率（FMPS）、最大吸光度（Amax）、凝固性维维蛋白原含量（Fc）、反应迟滞时间（DT）。结果Fbg的各项指标包括纤维蛋白单体聚合反应速率、最大吸光度、凝固性纤维蛋白原含量、反应迟滞时间，与对照组比较，差异均有统计学意义（P〈0，05—0．001）。结论失代偿肝硬化患者进行纤维蛋白原系列检测，能有效反映肝脏的损害程度，对临床治疗、预后具有重要的意义。

Changes of Plasma Fibrinogen in Patients with Decompensated Cirrhosis and its Clinical Significance

Objective To investigate the changes of plasma fibrinogen in patients with decompensated cirrhosis and its clinical significance. Methods Fibrin monomer polymerization velocity（ FMPV）, maximum attraction luminosity（Amax） ,fibrinogen con- centration （Fc） , reaction delayed time （DT） were detected in all patients. Results There were significant differences between the patient group and control group in these indices, such as FMPS,Amax, FC and DT（P 〈 0.05 or P 〈 0.001 ）. Conclusions De- compensated cirrhosis can be detected by serial measurement and analysis of fibrinogen, which are useful markers for determining the degrees of liver damage, it also provides basis for the treatment and prognosis.