| 线粒体乙醛脱氢酶2基因多态性对5-单硝酸异山梨酯缓释片对健康受试者药物代谢的影响 |
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| 引用本文： | 王平,刘玉清,蒋雄京,刘红,谢爽,田蕾,杜淑娴,许莉,李一石. 线粒体乙醛脱氢酶2基因多态性对5-单硝酸异山梨酯缓释片对健康受试者药物代谢的影响[J]. 中国临床药理学杂志, 2009, 25(5) |
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| 作者姓名： | 王平 刘玉清 蒋雄京 刘红 谢爽 田蕾 杜淑娴 许莉 李一石 |
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| 作者单位： | 1. 北京协和医学院、中国医学科学院,阜外心血管病医院卫生部,心血管药物临床研究重点实验室,北京,100037
2. 北京协和医学院、中国医学科学院,阜外心血管病医院心内科,北京,100037 |
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| 摘 要： | 目的 研究不同线粒体乙醛脱氢酶(ALDH2)基因型对5-单硝酸异山梨酯(IS-5-MN,抗心绞痛药)缓释片药物代谢的影响.方法 用PCR-RFLP测定ALDH2基因型后,分为2组,人组22名健康男性受试者.单次口服IS-5-MN 60 mg,血药浓度测定用HPLC-MS法;同时用脉搏波分析仪测量受试者脉搏波参数值;详细记录受试者的不良反应.结果 基因型为ALDH2*1/1和ALDH2*1/2的2组受试者在血药浓度、脉搏波参数、不良反应方面无明显差异;但同组内受试者的脉搏波参数值在服药前后有显著统计学差异(P＜0.05).结论 ALDH2基因多态性可能不影响IS-5-MN在健康受试者体内的代谢及药物作用.
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| 关 键 词： | 5-单硝酸异山梨酯缓释片 线粒体乙醛脱氢酶2 基因多态性 脉搏波分析 |
Effects of aldehyde dehydrogenase 2 gene polymorphism on the drug metabolism of isosorbide-5-mononitrate sustained-release tablets in healthy volunteers |
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| WANG Ping,LIU Yu-qing,JIANG Xiong-jing,LIU Hong,XIE Shuang,TIAN Lei,DU Shu-xian,XU Li,LI Yi-shi. Effects of aldehyde dehydrogenase 2 gene polymorphism on the drug metabolism of isosorbide-5-mononitrate sustained-release tablets in healthy volunteers[J]. The Chinese Journal of Clinical Pharmacology, 2009, 25(5) |
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| Authors: | WANG Ping LIU Yu-qing JIANG Xiong-jing LIU Hong XIE Shuang TIAN Lei DU Shu-xian XU Li LI Yi-shi |
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| Affiliation: | WANG Ping1,LIU Yu-qing1,JlANG Xiong-jing2,LIU Hong1,XIE Shuang 1,TIAN Lei1,DU Shu-xian1,XU Li1,LI Yi-shi1(1. Key Laboratory of Clinical Trial Research in Cardiovascular Drugs,Ministry of Health,2.Department of Cardiology,FuWai Cardiovascular Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China) |
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| Abstract: | Objective To investigate aldehyde dehydrogenase 2(ALDH2) gene polymorphism on the metabolism of isosorbide-5-mononitrate (IS-5-MN) sustained-release tablets in healthy volunteers.Methods Apply PCR-RFLP to measure the genotypes of ALDH2 gene,subjects are divided into two groups according to their genotypes. Twenty-two healthy subjects are selected to take 60 mg IS-5-MN in single does,plasma concentration of IS-5-MN are measured by HPLC-MS in different specific time. Use pulse wave appearance to measure pulse... |
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| Keywords: | isosorbide-5-mononitrate sustained-release tablets aldehyde dehydrogenase 2 genetic polymorphism pulse wave analysis |
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