奈西立肽对兔髂动脉球囊损伤后血管重塑及血浆醛固酮水平的影响

Objective To reveal the relation between Nesiritide and vascular remodeling,the relation between Nesiritide and the levels of aldosterone.Methods 20 male New Zealand rabbits were randomly divided into two groups.All rabbit models were constructed with BC.After injury,the control group were fed with standard forage,the Nesiritide group received standard forage plus subcutaneous Nesiritide0.1 mg/dissected free from arteria iliaca externa,processed for histological and morphological study by TD 2000 analysis system of pathology image.Data of vascular remodeling and the levels of plasma aldosterone were determined.Results There had significant difference between AUIEM and AUEEM(P ＜ 0.05),markedly significant difference was also found in residual cavity areas and ratios of stenosis(P ＜0.01).There had no significant difference between areas of media(P ＞ 0.05).Aldosterone reduced from the 28th day.Conclusions Nesiritide could benefit vascular remodeling after angioplasty,which might be through reducing aldosterone.

Effects of nesiritide on vascular remodeling and aldosterone in rabbits after angioplasty in arteria iliaca externa