甘氨双唑钠与顺铂在鼻咽癌放疗中增敏作用的比较

目的:比较甘氨双唑钠与顺铂在鼻咽癌放疗中的增敏作用。方法:将2008年1月-2010年6月于我院进行治疗的58例鼻咽癌患者随机均分为A、B组,2组分别在放疗的同期采用甘氨双唑钠或顺铂进行配合用药,治疗后比较2组患者的治疗总有效率和不良反应发生率以及治疗前、治疗后1个月及3个月的血清细胞角蛋白19片段(Cy211)、癌胚抗原(CEA)、肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)水平。结果:A组的治疗总有效率高于B组,不良反应发生率低于B组,治疗后1个月及3个月的血清Cy211、CEA、TSGF、VEGF水平均低于B组,差异有统计学意义(P<0.05或P<0.01)。结论:甘氨双唑钠在鼻咽癌放疗中的增敏作用优于顺铂,不良反应较低,综合优势明显。

Effects of Sodium Glycididazole and Cisplatin on Radiotherapy Sensitivity of Nasopharyngeal Carcinoma

OBJECTIVE： To investigate effects of sodium glycididazole and cisplatinof on radiotherapy sensitivity of nasopharyngeal carcinoma. METHODS： 58 patients with nasopharyngeal carcinoma in our hospital from Jan. 2008 to Jun. 2010 were selected as research object, and they were randomly divided into group A（29 cases） and group B（29 cases）. Then two groups were respectively treated with sodium glycididazole and cisplatin when they received radiotherapy. Then the total effective rate,incidence of adverse drug reactions and serum Cy211, CEA, TSGF and VEGF of 2 groups at first and third month before and after the treatment were analyzed and compared. RESULTS： The total effective rate of group A was higher than that of group B, and the incidence of adverse drug reactions was lower than that of group B,serum Cy211,CEA ,TSGF and VEGF at first and third month after the treatment were all lower than those of group B （P〈0.05 or P〈0.01）. CONCLUSION： The effects of sodium glycididazole on radiotherapy sensitivity of nasopharyngeal carcinoma is better than cisplatin, with low incidence of adverse drug reaction. The comprehensive advantage is obvious.