紫杉醇化疗前不同用药方案预防其过敏反应的疗效观察

目的:观察比较我院紫杉醇化疗前预防过敏反应简化用药方案与说明书标注的化疗前预防过敏反应用药方案的效果。方法:收集我院2010年初次使用紫杉醇化疗的恶性肿瘤患者182例,其中简化用药方案组(简化处理组)105例,说明书用药方案组(对照组)77例,比较2组使用紫杉醇注射液后过敏反应的发生率。结果:2组紫杉醇致过敏反应总发生率为2.7%,简化处理组紫杉醇致过敏反应发生率低于对照组(P<0.05),与文献报道的过敏反应发生率一致。结论:使用我院紫杉醇化疗前预防过敏反应简化用药方案的患者过敏反应发生率低于说明书用药方案,预防效果与说明书给药方案相似,而且具有给药简单、易被患者接受的优点,即使发生过敏反应,经处理使用化疗前简化方案仍可以使紫杉醇治疗得以继续,疗效肯定。

Efficacy Observation of the Preventive Effects of Different Preventive Treatments on Allergic Reaction Induced by Paclitaxel before Chemotherapy

OBJECTIVE： To observe and compare the preventive effects of 2 different preventive treatments, the paclitaxel instruction regimen and the simplified regimen, on allergic reaction induced by paclitaxel before treatment. METHODS： 182 patients with malignant tumor undergoing paclitaxel chemotherapy for the first time in early 2010 in our hospital were collected and divided into 2 groups, one group received the simplified regimen （simplified treatment group, n=105）, the other group received the paclitaxel instruction regimen （control group, n=77） before paclitaxel chemotherapy. The incidence of allergic reaction of Paclitaxel injection was compared between 2 groups. RESULTS： A total incidence of allergic reaction was 2.7%, and that of treatment group was lower than that of control group（P〈0.05）. It was in line with the incidence of allergic reaction reported in literatures. CONCLUSION： The incidence of allergic reaction in patients receiving simplified preventive regimen before paclitaxel chemotherapy is lower than those receiving instruction regimen, but the preventive effect of simplified preventive regimen is as good as instruction regimen. Simplified preventive regimen is simple and easily accepted by patients. Simplified preventive regimen given after allergic reaction occurs is effective and contributes to continuous implementation of paclitaxel chemotherapy.