灯盏花素对脑梗死患者神经功能缺损及血液流变学的影响

目的:探讨灯盏花素注射液对脑梗死患者神经功能缺损及血液流变学的影响。方法:将我院2006年1月-2010年2月收治的急性脑梗死患者158例,随机分为对照组(78例)与治疗组(80例)。2组均进行一般常规治疗,对照组在此基础上采用血栓通注射剂450mg,bid治疗;治疗组采用灯盏花素注射液15mL,qd治疗。2组均2周为1个疗程。治疗1个疗程后,观察2组临床疗效、神经功能缺损、血液流变学指标和不良反应情况,并进行统计、分析。结果:治疗组临床总有效率为90.0%,明显高于对照组的79.5%,2组比较差异有统计学意义(P<0.05);治疗组的神经功能评分情况和血液流变学指标均明显优于对照组,2组比较差异均有统计学意义(P<0.05)。2组均未见明显不良反应发生。结论:灯盏花素注射液治疗脑梗死疗效确切,神经功能及血液流变学指标明显改善,且不良反应少。

Effect of Breviscapine Injection on Neurologic Impairment and Blood Rheology in Patients with Cerebral Infarction

OBJECTIVE： To investigate the effect of Breviscapine injection on neurologic impairment and blood rheology in pa- tients with cerebral infarction. METHODS： 158 patients with acute cerebral infarction in our hospital from Jan. 2006 to Feb. 2010 were randomly divided into control group and treatment group. 78 cases in control group were given Xueshuantong injection（450 mg, bid）on the basis of conventional treatment, while 80 cases in treatment group were given Breviscapine injection（15 mL, qd）. Both groups were treated with 2 weeks for a treatment course. Their clinical effect, neurologic impairment, hemorheology indexes and adverse drug reactions were observed and analyzed statistically. RESULTS： The total effective rate of treatment group was 90.0%, which was obviously higher than control group （79.5%）, there was statistical significance （P〈0.05）. The neurologic impairment score and hemorheology indexes of treatment group were superior to control group, the difference had statistical signifi- cance （P〈0.05）. No obvious adverse drug reactions occurred in both groups. CONCLUSION： Breviscapine injection has obvious effect in the treatment of cerebral infarction with less adverse drug reactions.