阿托伐他汀对不稳定型心绞痛患者血脂和血浆炎症细胞因子的影响

目的:探讨阿托伐他汀对不稳定型心绞痛患者血脂和血浆炎症细胞因子的影响。方法:将64例不稳定型心绞痛患者随机均分为阿托伐他汀组和对照组。2组患者入院后均按照不稳定型心绞痛治疗方案进行治疗,阿托伐他汀组在此基础上加用阿托伐他汀片20mg.d-1,每晚睡前口服,连用8周。结果:阿托伐他汀组治疗8周后,血清胆固醇(TC)、甘油三酯(TG)、血清低密度脂蛋白胆固醇(LDL-C)水平均较治疗前明显下降(P<0.05),血清高密度脂蛋白胆固醇(HDL-C)水平较治疗前明显上升(P<0.05),而对照组治疗前、后均无明显变化(P>0.05)。2组血浆超敏C反应蛋白(hs-CRP)和肿瘤坏死因子(TNF)-α水平均较治疗前明显下降(P<0.05或P<0.01),且阿托伐他汀组比对照组下降幅度更明显(P<0.05)。结论:阿托伐他汀具有降脂、抗炎作用,能改善血管内斑块的炎症反应,具有良好的心血管保护作用。

Effect of Atorvastatin on Blood Lipids and Plasma Inflammatory Cytokines in Patients with Unstable Angina

To explore the effect of atorvastatin on blood lipids and plasma inflammatory cytokines in patients with unstable angina. METHODS：64 cases of unstable angina patients were randomly divided into atorvastatin group and control group. 2 groups of patients after admission in accordance with unstable angina treatment regimens for treatment, atorvastatin group based on those and combined with atorvastatin 20 mg.d-1 every night before bed, oral, 8 weeks. RESULTS： atorvastatin group af- ter 8 weeks, TC, TG, LDL-C level than before treatment was significantly decreased（P〈0.05）, HDL-C level increased significant- ly compared with those before treatment（P〈0.05）, while the control group before and after treatment in both groups showed no significant change（P〉0.05）. 2 groups of hs-CRP and TNF-ct level than before treatment was significantly decreased（P〈0.05 or P〈 0.01）, and the effects of atorvastatin group than in the control group decreased more obviously（P〈0.05）. CONCLUSION：Atorvas- tatin has lipid-lowering, anti-inflammatory effect, can improve the blood vessels within the plaque inflammation, has good cardio- vascular protective effect.