白芍总苷微囊的制备及其体外释药机制的研究

目的 制备白芍总苷PVA微囊并探讨其包封率及药物释放情况.方法 采用悬浮界面交联法对不同质量浓度的PVA白芍总苷微囊的制备进行考察,并采用紫外分光光度法绘制白芍总苷在人工肠液(pH 7.4)中的标准曲线.利用紫外分光光度法测定微囊的包封率和载药量,测定优化工艺后微囊在12 h内溶出的量并作释放度考察曲线.结果 通过界面交联法得到的白芍总苷微囊,干燥后平均粒径为10μm左右,其平均包封率和载药量依次为71.08%、7.32%.结论 紫外分光光度法测定肠溶微囊中白芍总苷的包封率、载药量及释放方法可靠,线性良好,稳定性好,PVA微囊使包封药物白芍总苷有肠溶特性.

Preparation and in vitro release mechanism of total glucosides of peony microcapsule

Objective To prepare total glucosides of peony (TGP) microcapsules through using suspension interfacial crosslinking method and to discuss encapsulation efficiency and drug release.Methods In this experiment,the preparation process of PVA microcapsules with different concentration was investigated by suspention interracial Crosslinking method and the typical curve of the TGP in the artifical intestinal fluid (pH 7.4) was drawn with using UV spectrophotometry.Its encapsulation efficiency and drug loading rate were determined by UV spectrophotometry,the dissolution volume of optimized microcapsules within 12 h and the curve of the release were measured.Results After drying,the average of the particle diameter was 10 μm,the encapsulation efficiency was 71.08%,and the drug-loading rate was 7.32%.Conclusion The results show that this method is reliable,stability,and good linearity.TGP dressing PVA microcapsules have enteric release property.