Impact of obesity on aortic root calcification and coronary calcification using multi-detector CT |
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| Affiliation: | 1. Internal Medicine Department, AL-Sader Teaching Hospital, Medicine College, Kufa University, Najaf, Iraq;2. Radiology Department, Medicine College, Kufa University, Iraq;1. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;2. Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada;3. Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael’s Hospital, Toronto, Ontario, Canada;4. Clinical Nutrition Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, Ontario, Canada;5. Division of Endocrinology and Metabolism, St. Michael’s Hospital, Toronto, Ontario, Canada;6. Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada;7. Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts;8. Keenan Research Centre for Biomedical Science, St. Michael''s Hospital, Toronto, Ontario, Canada;9. Division of Gastroenterology, St. Michael''s Hospital, Toronto, Ontario, Canada;10. AgroParisTech, Paris Institute of Technology for Life, Food and Environmental Sciences, Paris, France;11. College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;12. Department of Mathematics and Statistics, University of Windsor, Windsor, Ontario, Canada;1. Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School–University of Queensland School of Medicine, New Orleans, Louisiana;2. Department of Preventive Medicine, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana;3. Department of Human Performance and Sport Sciences, Winston-Salem State University, Winston-Salem, North Carolina;4. Department of Exercise Science and Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina;1. Department of Materials and Ceramic Engineering/CICECO – Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal;2. Mobility Engineering Center, Federal University of Santa Catarina (UFSC), 89218-000 Joinville, SC, Brazil;1. Ghent University, Laboratory for Chemical Technology, Technologiepark 914, Ghent, B-9052, Belgium;2. Boreskov Institute of Catalysis, 5, pr. Akad. Lavrentieva, 630090, Novosibirsk, Russia;3. Biomass Technology Group BV, Josink Esweg 34, 7545 PN, Enschede, The Netherlands |
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| Abstract: | ObjectiveThe impact of obesity measured by BMI on cardiovascular diseases remains controversial. We investigated the impact of obesity measured by BMI on the prevalence and correlation of aortic root calcification (ARC) and coronary artery calcification (CAC) in patients assessed by multi-detector CT (MDCT) angiography.Materials and methodsA total of 175 patients with intermediate pretest probability of ischemic heart disease based on age, sex, and symptoms who referred from cardiology clinic to 64-MDCT angiography examination for assessment of coronary artery disease were eligible for enrollment in this cross sectional study. The patients were divided into 2 groups according to their BMI. Non obese group (BMI < 25) composed of 73 (42%) patients (male 41 (56%), female 32 (44%) with a mean age 55 ± 8 years. Obese group (BMI ≥ 25) composed of 102 (58%) patients (male 45 (44%), female 58 (56%) with mean age 56 ± 7 years).ResultsARC was significantly associated with coronary artery calcification pattern in both non obese and obese groups (r = 461, P = 0.000) and (r = 0.358, P = 0.000) respectively. The significant association between ARC and CAC persisted even after adjustment for age, hypertension, smoking, hyperlipdemia and presence of multiple cardiac risk factor in both non obese and obese groups (95% C.I. = 0.106, 0.259, P = 0.000) and (95% C.I. = 0.108, 0.610, P = 0.006) respectively.ConclusionARC was significantly correlated with CAC irrespective of BMI status. |
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| Keywords: | Obesity BMI Coronary calcification Aortic root calcification MDCT |
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