烟酸缺乏症1例及文献复习

患者,女,63岁,颜面、双手背及双足背起红斑、水疱、糜烂及皲裂2周。皮损初起为水肿性潮红斑、水疱、糜烂,之后色泽变暗褐色,呈大片焦痂状,不久皮损肥厚,颜色变暗黑色,呈粗糙无弹性的黑色痂盖及皲裂。组织病理示:表皮角化过度,表皮不规则萎缩、灶性基层液化,真皮浅层水肿,可见色素颗粒及嗜酸性粒细胞,血管周围少量的淋巴细胞浸润。诊断:烟酸缺乏症。本文就其病因、临床表现、组织病理和治疗进行了文献复习。

One case with pellagra and Litereture Review

One patient,aged 63 yers old.Face,hands,and feet on her own back erythema,blisters,erosions and chapped two weeks.Early lesions of edema tide erythema,blisters,erosions,and then become dark brown color,showing large areas of eschar-like,soon,hyperfrophic lesions,dark color change,was rough inelasric black scab cover and chapped.Histopathology showed:epidermal hyperkeratosis,irregular epidermal atrophy,focal primary liquefaction,dermal edema,visible pigment granules and eosinophils,perivascular infiltration of small lymphocytes.Pellagra was diagnosed.Its etionlogy,clinical manifestations,pathophysiology and treatment were reviewed.