糖尿病肾病内热证与肾功能及炎症因子的相关性研究

目的:观察糖尿病肾病不同分期内热证与肾功能及炎症指标的相关性。方法:收集202例糖尿病肾病患者的临床资料,采用酶联免疫吸附法检测微炎症指标,包括超敏C反应蛋白(high-sensitivity C-reactive protein,HS-CRP)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α),进行统计分析。结果:与非内热证组比较,中期、晚期内热证组24小时尿蛋白定量明显升高;晚期内热证组的血清肌酐明显升高,肾小球滤过率(glomerular filtration rate,GFR)明显降低;炎症因子CRP、IL-6、TNF-α随疾病进展均呈上升趋势;晚期内热证组与非内热证组比较,IL-6、TNF-α升高;中期HS-CRP与内热积分呈正相关,晚期TNF-α与内热积分呈正相关。结论:内热病机贯穿于糖尿病肾病的始终,与糖尿病肾病肾功能以及疾病进展密切相关;同时,内热积分与炎症因子HS-CRP、TNF-α的表达存在一定的相关性,这种相关性在疾病中期、晚期表现更加明显。

Study on Correlation of Renal Function and Inflammatory Factors in DKD Patients with Inner Heat Syndrome

Objective: To observe the correlation between renal function and inflammation indexes HS-CRP,IL-6,TNF-α in different stages of diabetic nephropathy with inner Heat Syndrome. Methods: The clinical data of 202 patients with diabetic nephropathy were collected,and the micro-inflammatory indicators of high-sensitivity C-reactive protein (HS-CRP),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected with enzyme-linked immunosorbent assay. Results: Compared with the non-endothermic syndrome group,the 24-hour urinary protein was significantly increased in the middle and late endometrial syndrome groups;the serum creatinine was significantly increased,and the glomerular filtration rate (GFR) was significantly reduced;Inflammatory factors CRP,IL-6,TNF-α all show an upward trend with the progression of the disease;Compared with the non-endothermic syndrome group,the levels of IL-6 and TNF-α are increased in the late-stage fever group;,Late TNF-α is positively correlated with internal thermal score. Conclusion: The endometrial disease mechanism runs through the diabetic nephropathy and is closely related to the renal function and disease progression of the diabetic nephropathy. At the same time,there is a certain correlation between the endothermic score and the expression of the inflammatory factors HS-CRP and TNF-α. This correlation is the middle and late stages of the disease are more pronounced.