普拉洛芬联合玻璃酸钠治疗干眼的临床观察

目的对普拉洛芬联合玻璃酸钠与单纯使用玻璃酸钠治疗干眼进行临床观察。方法将180例干眼患者随机分为观察组与对照组,观察组采用普拉洛芬联合玻璃酸钠治疗,对照组采用单纯玻璃酸钠治疗,通过比较两组患者治疗前后的泪膜破裂时间、泪液分泌试验、角膜荧光素染色评分、干眼症状评分的变化,观察两种治疗方法的临床疗效。结果两组治疗的临床有效率分别为95.56%和83.33%,观察组临床有效率优于对照组(P<0.05);治疗后2周、4周两组泪液分泌试验、泪膜破裂时间比较,观察组均高于对照组,差异有统计学意义(P<0.05);治疗后2周、4周两组干眼症状评分、角膜荧光素染色评分比较,观察组均低于对照组,差异有统计学意义(P<0.05)。结论对于干眼患者,从临床有效率、干眼症状评分、泪液分泌试验、泪膜破裂时间及角膜荧光素染色评分等方面分析,普拉洛芬联合玻璃酸钠组治疗方案优于单纯使用玻璃酸钠,值得临床推广应用。

Clinical Observation on Praloprofen Combined with Sodium Hyaluronate in the Treatment of Dry Eye Disease

Objective To clinically evaluate pranoprofen combined with sodium hyaluronate and sodium hyaluronate alone for the treatment of dry eye disease.Methods A total of 180 patients with dry eye disease were randomly divided into an observation group and a control group.The observation group was treated with pranoprofen combined with sodium hyaluronate.The control group was treated with simple sodium hyaluronate.By comparing the changes of tear film rupture time,tear secretion test,corneal fluorescein staining score,and scores of dry eye disease symptoms before and after treatment in the 2 groups,the clinical efficacy of the 2 treatment methods were observed.Results The clinical effect rates of the 2 groups were 95.56%and 83.33%,respectively,and the observation group was better than the control group(P>0.05).In the comparison of the tear secretion test and tear film rupture time between the 2 groups at 2 and 4 weeks after treatment,the observation group was higher than the control group,and the difference was statistically significant(P<0.05);In the comparison of dry eye symptoms score and corneal fluorescein staining score at 2 and 4 weeks after treatment,the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusions For dry eye disease patients,from the analysis of clinical effective rate,scores of dry eye disease symptoms,tear secretion test,tear film rupture time and corneal fluorescein staining score,pranoprofen combined with sodium hyaluronate treatment program is better than the simple use of sodium hyaluronate,which is worthy of clinical promotion and application.