长春西汀对腔隙性梗死患者认知功能及神经功能的影响

目的探讨长春西汀联合小牛血清去蛋白对腔隙性梗死患者认知功能及神经功能的影响。方法选取2017-07—2019-07郑州大学第五附属医院收治的100例腔隙性梗死患者的病历资料进行回顾性分析,随机分为单药组和联合组。单药组给予注射小牛血清去蛋白,联合组在单药组基础上给予长春西汀治疗,2组连续治疗2周,并随访半年。根据NIHSS评分量表评估2组神经功能,根据MMSE评分量表评估认知功能,根据Barthel指数计分法(BI)评估生活质量,并观察患者治疗期间的不良反应。结果治疗后联合组NIHSS评分(2.39±0.74)分明显低于单药组(3.76±1.15)分,联合组MMSE评分(27.17±5.24)分明显高于单药组(24.36±5.39)分,联合组BI指数(68.55±7.91)分明显高于单药组(61.48±8.27)分,差异均有统计学意义(P<0.05)。2组不良反应发生情况无明显差异。结论长春西汀联合小牛血清去蛋白更有助于腔隙性梗死患者神经功能和认知功能的恢复,值得临床应用。

Effect of vinpocetine on cognitive function and nervous function in patients with lacunar cerebral infarction

Objective To investigate the effects of vinpocetine combined with calf serum deproteinization on cognitive function and neural function in patients with lacunar infarction.Methods The medical records of 100 patients with lacunar cerebral infarction admitted to our hospital from July 2017 to July 2019 were selected for retrospective analysis.They were divided into single-agent group and combined group according to different treatment methods.The single drug group was injected with calf serum deproteinized,and the combined group was additionally injected with vinpocetine.Both groups were treated continuously for two weeks and followed up for six months.The neurological function was evaluated according to the NIHSS scale,the cognitive function was evaluated according to the MMSE scale,and the quality of life was evaluated according to the Barthel index(BI)score,and observe and record the adverse reactions of patients during treatment.Results After treatment,the NIHSS score of the combined group(2.39±0.74)was significantly lower than that of the single drug group(3.76±1.15),and the score of the MMSE(27.17±5.24)of the combined group was significantly higher than that of the single drug group(24.36±5.39).The BI(68.55±7.91)was significantly higher than that of the single drug group(61.48±8.27),and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Vinpocetine combined with calf serum deproteinization can help restore neurological and cognitive functions in patients with lacunar infarction,and is worthy of clinical promotion.