小剂量肝素联合奥曲肽对原发性肝癌TACE术后肝外转移的影响

目的 观察小剂量肝素联合奥曲肽对原发性肝癌TACE术后肝外转移的影响.方法 共入组147例原发性肝癌患者,分为对照组63例和治疗组84例,均行TACE治疗.治疗组术前2天予静脉输注小剂量肝素(1250～2500U),每天1次,共10～14天;术前给于奥曲肽0.1mg皮下注射,行TACE术同时予奥曲肽25μg/h静脉滴注...

Clinical observation of transcatheter hepatic arterial chemoembolization combined with low-dose heparin and octreotid on extrahepatic metastasis of primary hepatocellular carcinoma

Objective To evaluate the effect of transcatheter hepatic arterial chemoembolization（TACE） combined with low-dose heparin and octreotid on extrahepatic metastasis of primary hepatocellular carcinoma.Methods Both the control group and treatment group were treated by TACE.In addition,treatment group was treated by low-dose heparin（1250-2500U intervenous infusion,once a day for 10-14 days pre-operation） and SMS 201-995 octreotide（0.1mg hypodermic injection 30min pre-operation and intervenous infusion 72h with the speed of 25μg/h）.The two groups underwent TACE once a month,and efficacy,quality of life and side effects were evaluated after 2-4 times treatment.Results There was no statistical significant of variation of primary lesion between the two group（P0.05）.The incidence of tumor metastasis 3,6,9,12 months after TACE in control group was 4.7%,12.7%,12.7% and 25.4% compared with 1.1%,3.5%,3.5% and 4.8% in treatment group with statistic significance（P0.05）.The arise of AFP level 6,9,12 month after TACE in control group was 7.9%,19.0% and 31.7% compared with 6.0%,9.5% and 11.9% in treatment group with statistic significance（P0.05）.Quality of life,side effect and blood coagulation did not show difference between the two groups.Conclusion The incidence of tumor metastasis can be depressed by the combination of low-dose heparin and octreotide after TACE of primary hepatocellular carcinoma,and won＇t increase the side effect and influence on primary lesion and blood coagulation.