阿立哌唑与氟哌啶醇治疗精神分裂症对照研究

目的:评价阿立哌唑与氟哌啶醇治疗精神分裂症的疗效及安全性。方法:阿立哌唑组50例,氟哌啶醇组48例,以阳性与阴性症状量表(PANSS)、临床疗效总评量表疾病严重程度(CGI-SI)、治疗中出现的症状量表(TESS)、锥体外系反应量表(RSESE)评定疗效及不良反应。疗程6周。结果:两组疗效相仿。阿立哌唑组PANSS阴性症状因子减分在治疗后4及6周显著优于氟哌啶醇组。阿立哌唑组不良反应显著较少。结论:阿立哌唑是一有效安全的抗精神病药。

Comparison study of aripiprazole and haloperidol in treatment of schizophrenia

Objective:To compare the efficacy and safety of aripiprazole and haloperidol in treatment of schizophrenia.Method:Antipsychotic efficacy was assessed by positive and negative symptom scale(PANSS)and clinical global impressions-severity of illness rating scale(CGI-SI),antipsychotic side effect was assessed by treatment emergent symptom scale(TESS)and rating scale for extrapyrarnidal side effects(RSESE)in 50 patients treated by aripiprazole(aripiprazole group)and 48 patients treated by haloperidol(haloperidol group)for six weeks.Results:The efficacy was similar in two groups.The reduction of total negative score in patients of aripiprazole group was significantly higher than that in haloperidol group after 4 and 6 weeks.Patients in aripiprazole group had significantly less side effects.Conclusion:Aripiprazole is an effective and safe antipsychotic.