我院临床常见病原菌耐药性分析

目的：了解我院2008—2009年院内常见致病菌对不同类型抗菌药的耐药情况，为临床合理使用抗菌药提供依据。方法：对临床送检标本中培养分离的常见致病菌：肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌、白念珠菌、粘质沙雷菌、嗜麦芽窄食单胞菌、金黄色葡萄球菌进行分析，并与2006—2007年度全国细菌耐药监测结果进行对比。结果：我院铜绿假单胞菌（12．32％）对抗菌药的耐药率于全国平均水平类似，金葡菌（5．44％）耐药率略低于全国平均水平，肺炎克雷伯菌（14．24％）、铜绿假单胞菌（12．32％）、大肠埃希菌（11．36％）耐药率高于全国平均水平，MRSA检出率为29．41％，未检出耐万古霉素及替考拉宁菌株；大肠埃希菌、克雷伯菌中产ESBLs检出率分别为6．6％和10．12％。结论：我院细菌耐药情况不容乐观，继续开展细菌耐药监测，对指导临床合理应用以及经验应用抗菌药具有重要意义。

Analysis of Clinical Drug Resistance Against Common Pathogenic Bacteria

Objective ： To analyze the drug resistance against different types of common pathogenic bacteria in our hospital in 2008 -2009 to provide the basis for the rational use of antimicrobial agents. Method：The clinically cultured and isolated specimens for inspection of common pathogens ： Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Stenotrophomonas maltophilia, Staphylococcus aureus were analyzed and compared with the 2006 -2007 annual national antimicrobial resistance monitoring results. Result： The resistance rate Pseudomonas aeruginosa （12.32%） was similar to the national average, Staphylococcus aureus （5.44%） was slightly lower than the national average,the resistance rates of Klebsiella pneumoniae （ 14.24% ） , Pseudomonas aeruginosa （ 12.32% ） and Escherichia coli （11.36%） were higher than the national average. MRSA detection rate was 29.41% but no drug resistance was detected against vancomycin and teicoplanin strains. The detection rates of Escherichia coli, Klebsiella producing ESBLs were 6.6% and 10.12%. Conclusion：The overall drug resistance against bacteria was not considered to be well handled in our hospital so that it should continue to monitor the antimicrobial resistance, which meant a lot in guiding clinical antimicrobial drugs use.