| 基于Zelen's设计桂葛灵仙汤联合颈夹脊穴透灸法治疗神经根型颈椎病风寒湿痹证 |
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| 引用本文： | 孙鹏,李建,樊炜骏,唐宁,沙明波,鲁育,李华南,王舒. 基于Zelen's设计桂葛灵仙汤联合颈夹脊穴透灸法治疗神经根型颈椎病风寒湿痹证[J]. 中国实验方剂学杂志, 2020, 26(9): 58-63 |
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| 作者姓名： | 孙鹏 李建 樊炜骏 唐宁 沙明波 鲁育 李华南 王舒 |
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| 作者单位： | 天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193,天津中医药大学 第一附属医院, 天津 300193 |
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| 基金项目： | 国家自然科学基金项目（81603711） |
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| 摘 要： | 目的:基于Zelen's设计,探讨桂葛灵仙汤联合夹脊穴透灸法治疗神经根型颈椎病(CSR)风寒湿痹证临床疗效及作用机制。方法:将120例CSR风寒湿痹证患者随机分为中药组和联合组,均60例,拟入中药组直接进入中药组,拟入联合组知情同意则进入联合组,不同意则进入中药组。中药组给予桂葛灵仙汤150 m L/次,2次/d口服,联合组患者在中药组治疗基础上给予颈部夹脊穴透灸治疗,30 min/次,1次/d,两组患者均治疗8周。记录入组患者CSR 20分量表评分,SF-36量表评分及典型症状体征缓解时间,治疗结束后统计总有效率和治愈率;酶联免疫夹心法检测治疗前后患者血清白三烯B_4(LTB_4),白三烯C_4(LTC_4),白三烯D_4(LTD_4),甲壳质酶蛋白-40(YKL-40),白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)含量。结果:联合组总有效率为98.11%(52/53),治愈率为43.39%(23/52),优于中药组总有效率91.04%(61/69),治愈率20.89%(14/67)(P0.05);与中药组比较,联合组患者CSR 20分量表,SF-36量表评分升高(P0.05),典型症状体征缓解时间缩短(P0.05);血清中LTB_4,LTC_4,LTD_4,YKL-40,IL-1β及TNF-α含量降低(P0.05)。结论:Zelen's设计结果显示桂葛灵仙汤联合夹脊穴透灸法治疗CSR风寒湿痹证临床疗效确切,值得临床推广,其机制可能与抑制LT表达,减少IL-1β及TNF-α含量在血清中含量,从而促进颈椎软骨修复和提高疼痛阈值有关。
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| 关 键 词： | 桂葛灵仙汤 神经根型颈椎病 透灸法 白三烯 炎症 桂枝加葛根汤 |
| 收稿时间： | 2019-06-02 |
Effect of Zelen's Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome |
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| SUN Peng,LI Jian,FAN Wei-jun,TANG Ning,SHA Ming-bo,LU Yu,LI Hua-nan and WANG Shu. Effect of Zelen's Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome[J]. China Journal of Experimental Traditional Medical Formulae, 2020, 26(9): 58-63 |
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| Authors: | SUN Peng LI Jian FAN Wei-jun TANG Ning SHA Ming-bo LU Yu LI Hua-nan WANG Shu |
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| Affiliation: | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | Guige Lingxian decoction cervical spondylotic radiculopathy moxibustion leukotriene inflammation Guizhi Jia Gegentang |
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