| 腺苷酸活化蛋白激酶在酒精性肝病中的研究进展 |
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| 引用本文： | 魏峰,周俊英. 腺苷酸活化蛋白激酶在酒精性肝病中的研究进展[J]. 国外医学:内科学分册, 2009, 36(12): 726-729 |
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| 作者姓名： | 魏峰 周俊英 |
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| 作者单位： | 河北医科大学第三医院感染科,河北,石家庄,050051;河北医科大学第三医院感染科,河北,石家庄,050051 |
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| 摘 要： | 腺苷酸激活蛋白激酶（AMPK）信号通路是调节细胞能量状态的中心环节,其激活后磷酸化下游的信号分子,抑制ATP合成,同时促进ATP分解,被称为“细胞能量调节器”,在增加脂肪酸氧化、胰岛素敏感性及氧化应激等方面发挥重要作用,可能参与酒精性肝病的发病过程。该文就AMPK在酒精性肝病发病机制中的作用作一综述。
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| 关 键 词： | 腺苷酸激活蛋白激酶 酒精性肝病 胰岛素抵抗 |
Studies on AMP-activated protein kinase and alcoholic liver disease |
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| WEI Feng,ZHOU Jun-ying. Studies on AMP-activated protein kinase and alcoholic liver disease[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(12): 726-729 |
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| Authors: | WEI Feng ZHOU Jun-ying |
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| Affiliation: | WEI Feng,ZHOU Jun-ying.Department of Infectious Disease,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China |
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| Abstract: | The AMP-activated protein kinase(AMPK) acts as a sensor of cellular energy status.Once being activated,AMPK switches on catabolic pathways that generate ATP,while switching off ATP consuming processes.It plays an important role in increasing fatty acid oxidation,insulin sensibility and oxidative stress.It can take part in the pathogenesis of alcoholic liver disease(ALD).In this review,we summarized the role of AMPK in the pathogenesis of ALD. |
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| Keywords: | AMP-activated protein kinase Alcoholic liver disease Insulin resistance |
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