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| 尼莫地平对体外培养脑胶质瘤细胞增殖及DNA合成的影响 | |
| 引用本文： | 胡应礼 浦佩玉. 尼莫地平对体外培养脑胶质瘤细胞增殖及DNA合成的影响[J]. 中国肿瘤临床, 1993, 20(3): 177-180 |
| 作者姓名： | 胡应礼 浦佩玉 |
| 作者单位： | 天津市神经病学研究所神经肿瘤室 (天津市300052) |
| 摘 要： | 本文采用集落形成实验,细胞生长曲线和[~3H」-TdR掺入实验的方法观察了尼莫地平的体外抗肿瘤作用。结果表明,尼莫地平对恶性星形细胞瘤体外细胞系TJ_(861)细胞的集落形成率、细胞生长率及DNA合成均有较明显的抑制作用。 |
| 关 键 词： | 尼莫地平 DNA 脑胶质瘤 |
Effect of Nimodipine on Proliferation and DNA Synthesis of Malignant Glioma Cells in vitro |
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| Hu Ying-Li Pu Pei-Yu Neurological Institute,Tianjin Medical College Hospital,Tianjin. Effect of Nimodipine on Proliferation and DNA Synthesis of Malignant Glioma Cells in vitro[J]. Chinese Journal of Clinical Oncology, 1993, 20(3): 177-180 | |
| Authors: | Hu Ying-Li Pu Pei-Yu Neurological Institute Tianjin Medical College Hospital Tianjin |
| Abstract: | Effects of Nimodipine on the cells of a malignant astrocytoma cell line TJ861 were studied in vitro. The results showed that Nimodipine inhibited the colony formation of the cells and the cell proliferation rate as compared to the control group. (~3H)-TdR incorporation test on DNA synthesis indicated that DNA synthesis of TJ861 cells were al- so partially blocked by Nimodipine. It is suggested that Nimodipine is a potential antitumor agent. |
| Keywords: | Nimodipine Glioma cells DNA synthesis |
| 本文献已被 CNKI 维普 等数据库收录！ | |