视黄醇结合蛋白4与冠心病的相关性探讨

目的：探讨研究视黄醇结合蛋4（PaB4）与冠心病（CHD）的相关性。方法：选择100铆研究对象。其中冠心痛组60倒和对照组40例,均采用酶联免疫吸附法（rUSA）测定血浆RPB4水平,测量身高,体重,腰臀比值（WHR）,血压等,并采集记录相应生化数据：FPG、糖化血红蛋白（HbAle）、总胆固醇（TC）、三酯酰甘油。（TG）、血清高密度脂蛋白胆固醇（HDL—c）、血清低密度脂蛋白胆固醇（LDL—c）、超敏C反应蛋白（hs—cRP）,应用统计软件进行统计检验。结果：冠心痛组血浆RPB4水平明显高于正常对照组[（44．82±15．88）,（36．60±12．20）,P〈0．05].相关分析显示冠心病忠孝血清RBP4水平与WHR,SBP,TG,ha—CRP,FPG,HOMA—IR呈正相关。结论：血清RBP4与冠心痛存在一定的相关性,呵能与斑块稳定性有关,可作为预测斑块稳定性的血清标志物。

RELATIONSHIP BETWEEN RETIONL BINDING PROTEIN 4 AND CARDIOVASCULAR DISEASE

Objective： To investigate the relationship between the plasma] retinol binding protein 4 （RBP4） levels and cardiovascular disease. Methods：Totally100 subjects were divided into two groups： eontrols（n =40）and patiems with CHD（n =60）, Plasma] RBP4 levels were measured by ELISA, Meanwhile, FPGHbAlc.TCTG HI）L- CLDL- Chs- CRP and blood pressure were measured subgroups. Results： Plasma] RBP4 levels in patients with CHD were significantly higher than that of controls, and compared between the two levels was positively correlated with WHR, SBP, TG, hs - CRP, FPG, and In （ HOMA IR）. Condusion： Elevated RBP4 levels might affect the develovment of cardiovascular disease. RBP4 may act as one of vulnerable Dlanues. and be correlated with CHD.