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Reduction of transforming growth factor‐β type II receptor is caused by the enhanced ubiquitin‐dependent degradation in human renal cell carcinoma
Authors:Hirotaka Fukasawa  Tatsuo Yamamoto  Yoshihide Fujigaki  Taro Misaki  Naro Ohashi  Tatsuya Takayama  Sayuri Suzuki  Soichi Mugiya  Toshiaki Oda  Chiharu Uchida  Kyoko Kitagawa  Takayuki Hattori  Hidetoshi Hayashi  Seiichiro Ozono  Masatoshi Kitagawa  Akira Hishida
Affiliation:1. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, JapanTel: +81‐53‐435‐2261, Fax: +81‐53‐434‐9447;2. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan;3. Department of Health and Nutritional Sciences, Hamamatsu University, Hamamatsu, Shizuoka, Japan;4. Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan;5. Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan;6. Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan
Abstract:
Keywords:transforming growth factor‐β   (TGF‐β  )  TGF‐β   type II receptor (Tβ  R‐II)  renal cell carcinoma (RCC)  ubiquitination  Smad‐ubiquitination regulatory factor 2 (Smurf2)
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