丹红注射液对冠状动脉支架置入患者血管内皮功能的影响(英文)

背景:众多研究证实丹参能抑制中性粒细胞的黏附、聚集及氧自由基的产生,具有活血化瘀的疗效,但目前对于其保护血管内皮以及抗血栓形成具体机制,尤其是在冠状动脉支架置入后作用机制的研究很少.目的:观察丹红注射液对急性冠脉综合征患者冠状动脉支架置入前后血管内皮功能的影响.方法:采用随机对照方法将60例急性冠脉综合征患者分为2组,常规治疗组在冠状动脉支架置入后给予常规药物治疗;丹红组在冠状动脉支架置入后给予常规药物治疗基础上加用丹红注射液20 mL/d,疗程10 d.支架置入前后及丹红治疗前后测定内皮依赖性血流介导的血管舒张反应、血浆内皮素、血栓烷B2、6-酮-前列腺素水平,双重评价其血管内皮功能;同时观察两组患者近期预后.结果与结论:与支架置入前比较,支架置入后两组患者血浆内皮素、血栓烷B2均明显提高,6-酮-前列腺素水平明显下降(P<0.05).与支架置入后比较,两组治疗后血浆内皮素、血栓烷B2均明显降低(P<0.05,P<0.01);内皮依赖性血流介导的血管舒张反应、6-酮-前列腺素明显提高(P<0.05,P<0.01),丹红组更明显(P<0.05).住院期间丹红组心血管事件发生较常规治疗组略有下降,但差异无显著性意义(P>0.05).结果表明丹红注射液可显著改善支架置入急性冠脉综合征患者血管内皮功能,使血管舒张,改善供血,抑制血小板聚集,且有改善近期预后的倾向.

Danhong injection effects on vascular endothelial function in patients undergoing coronary artery stent implantation

BACKGROUND:Numerous studies have shown that Danshen Root can suppress adhesion and aggregation of neutrophils as well as production of oxygen free radical,can activate blood circulation to dissipate blood stasis.However,there are few studies about precise mechanisms underlying protection of vascular endothelium and anti-thrombosis,especially concerning the mechanism of action following coronary artery stent implantation.OBJECTIVE:To investigate the influence of Danhong injection on vascular endothelial func...