生物型人工肝的肝细胞源研究进展

各种原因所致的肝功能衰竭是一种病死率高的并发症。肝移植是治疗肝衰竭最有效的手段。为了替代肝脏移植,以肝细胞为基础的生物型人工肝(BAL)成为目前肝功能衰竭治疗的基础与临床研究的重点和热点。肝细胞是BAL的生物部分,起着核心作用;应用于BAL的肝细胞主要有:原代肝细胞(包括同源的人肝细胞及异种肝细胞)、各种不同来源的肝细胞株、干细胞等。此文就涉及肝细胞源研究的最新进展作简要综述。

Progress of hepatocytes and cell sources for bioartificial liver

Liver failure is an uncommon,devastating syndrome,which results in death.Orthotropic liver transplantation(OLT) is the most curative therapy for patients with liver failure.As an alternative to liver transplantation,researches have been worked toward the goal of development of full functional artificial liver.Hepatocytes are the very important element of bioartificial liver(BAL),which is powerful therapeutic application for treating liver failure.The properties of the hepatocytes will directly affect the cu...