血清高半胱氨酸与脑梗死严重程度及中医证型关系的研究

为探讨血清高半胱氨酸水平与脑梗死严重程度及中医证型之间的关系 ,选取 115例脑梗死患者及 5 0例健康者 ,对血清高半胱氨酸水平与患者脑梗死严重程度、中医证型的关系进行分析。结果 :脑梗死患者血清高半胱氨酸水平明显高于正常人 (P <0 0 0 1) ;不同神经功能缺损程度之间血清高半胱氨酸水平有显著性差异 (P <0 0 1) ,且与脑梗死的严重程度一致 ;脑梗死各中医证型血清高半胱氨酸水平比较 ,中脏腑较中经络显著升高 (P <0 0 0 1) ,实证高于虚实夹杂证和虚证 (P <0 0 5 )。提示 :血清高半胱氨酸水平与脑梗死严重性呈正相关 ;血瘀痰阻是导致脑梗死的病理基础。

Relationship Between TCM Syndrome and Serum Homocysteine and Severity of Cerebral Infarction

This paper studied the relationship between TCM syndrome and serum homocystein (Hcy) and severity of cerebral infarction. Serum Hcy was dete rmined by high-performance liquid chromatography with fluorescence in 115 patie nts with cerebral infarction and 50 healthy people; the relationship between Hcy level and the severity of cerebral infarction and TCM syndrome was analyzed. Re sults: The Hcy level was significantly higher in patients with cerebral infarcti on than in healthy people (P<0.001); Hcy levels were obviously significant i n patients with different nerve defects (P<0.01), according with the severit y of cerebral infarction; the Hcy levels in patients with cerebral infarction in volving viscera were remarkably higher than those cases involving meridians (P <0.001); in TCM syndrome, Hcy levels were higher in the excess syndrome than i n deficiency syndrome (P<0.05). It is demonstrated that the level of serum H cy is in direct proportion with the severity of cerebral infarction; that blood -stasis and phlegm obstruction are the pathogenic foundation of cerebral infarc tion; the levels of serum Hcy can provide some evidence for TCM syndrome differe ntiation.