奥沙利铂联合醛氢叶酸和5-氟尿嘧啶治疗晚期胃癌的疗效观察

目的 :观察奥沙利铂 (L - OHP)联合醛氢叶酸 (L V)和 5 -氟尿嘧啶 (5 - Fu)组成的 OL F方案治疗晚期胃癌的疗效及毒副作用。方法 :OL F组 4 0例 :L - OHP 130 mg/m2 ,静滴 ,0 h～ 2 h,第 1天 ;L V 10 0 mg/m2 ,静滴 ,0 h～ 2 h,第 1天～第 5天 ;5 - Fu 5 0 0 mg/m2 ,静滴 ,2 h～ 12 h,第 1天～第 5天。FL P组 4 0例 :DDP 2 0 m g/m2 ,静滴 ,第 1天～第 5天 ;L V 10 0 mg/m2 ,静滴 ,0 h～ 2 h,第 1天～第5天 ;5 - Fu 5 0 0 mg/m2 ,静滴 ,2 h～ 12 h,第 1天～第 5天。以上方案均为每 3周重复。结果 :OL F组和FL P组的有效率分别为 6 2 .5 %和 4 0 .0 % (P<0 .0 5 ) ;中位疾病进展时间 (time to progression,TTP)分别为 2 8周和 2 2周 (P<0 .0 5 )。结论 :OL F方案治疗晚期胃癌 ,较 FL P方案疗效明显提高 ,延长了患者无病生存期并改善了患者生活质量。

A CLINICAL RANDOM STUDY ON OXALIPLATIN COMBINED WITH LEUCOVORIN AND FLUOROURACIL IN THE TREATMENT OF ADVANCED GASTRIC CARCINOMA

Objective:To compare the clinical efficacy and toxicity for advanced gastric carcinoma using OLF (L-OHP/LV/5-Fu) regimen or FLP (DDP/LV/5-Fu) regimen.Methods:40 cases were treated with OLF regimen (L-OHP 130 mg/m 2,d1, LV 100 mg/m 2,d1~5, 5-Fu 500 mg/m 2,d1~5) and the other 40 cases were treated with FLP regimen (DDP 20 mg/m 2,d1~5, LV 100 mg/m 2,d1~5, 5-Fu 500 mg/m 2,d1~5). All repeated every 3 weeks.Results:The response rates of the OLF and FLP regimen were 62.5 % Vs 40.0 % ( P <0.05). The time to progression (TTP) were 28 weeks vs 22 weeks ( P <0.05).Conclusion:OLF regimen may be promising for treating advanced gastric cancer and it is worthy of further clinical trial.