| 作用于VEGF信号通路的血管生成抑制剂 |
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| 引用本文： | 万博,刘煜. 作用于VEGF信号通路的血管生成抑制剂[J]. 药学进展, 2010, 34(6): 256-263. DOI: 10.3969/j.issn.1001-5094.2010.06.003 |
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| 作者姓名： | 万博 刘煜 |
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| 作者单位： | 中国药科大学生化教研室,江苏,南京,210009 |
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| 基金项目： | 国家"重大新药创制"科技重大专项 |
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| 摘 要： | 分类介绍作用于血管内皮细胞生长因子信号通路的血管生成抑制剂研究近况以及该类药物存在的缺陷。血管生长促进因子和血管抑制因子的活性及其表达水平对肿瘤的发生和发展具有关键性的作用,所以,针对于血管生成,尤其是靶向于血管内皮细胞生长因子的药物已成为近年来抗肿瘤药物研究的热点之一。
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| 关 键 词： | 血管内皮细胞生长因子 靶向治疗 血管生成抑制剂 |
Vascular Endothelial Growth Factor Signaling Pathway-targeted Angiogenesis Inhibitors |
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| WAN Bo,LIU Yu. Vascular Endothelial Growth Factor Signaling Pathway-targeted Angiogenesis Inhibitors[J]. Progress in Pharmaceutical Sciences, 2010, 34(6): 256-263. DOI: 10.3969/j.issn.1001-5094.2010.06.003 |
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| Authors: | WAN Bo LIU Yu |
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| Affiliation: | (Department of Biochemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Vascular endothelial growth factor（VEGF） signaling pathway-targeted inhibitors were introduced.Tumor growth,invasion and metastasis are all blood vessel-dependent but the activity and expressing level of blood vessel growth-promoting factors and inhibiting factors are considered to be the most important to angiogenesis.In recent years,the cancer therapy has focused on developing molecular targeted drugs,especially angiogenesis-targeted drugs,such as VEGF signaling pathway-targeted inhibitors. |
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| Keywords: | vascular endothelial growth factor targeted therapy angiogenesis inhibitor |
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