Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases |
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| Affiliation: | 1. Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Piazzale Scuro, 10, 37134 Verona, Italy;2. Department of Surgery, Section of Anatomical Pathology, San Bortolo Hospital, Vicenza, Italy;3. Primary Care Department, Azienda ULSS20 Verona, Verona, Italy;4. South London and Maudsley NHS FoundationTrust, Denmark Hill, London SE5 8AZ, United Kingdom;5. Institute of Psychiatry, Psychology and Neuroscience, King''s College London, De Crespigny Park, London SE5 8 AF, United Kingdom;6. Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, United Kingdom;7. Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy;8. National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy;9. Institute for clinical Research and Education in Medicine (IREM), Padova, Italy;1. Cancer Prevention and Control Program, Fox Chase Cancer Center, PA, USA;2. Department of Community Health and Psychiatry, University of West Indies, Mona, Jamaica;3. Division of Population Sciences, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA;4. Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA, USA;5. Molecular and Cellular Biology Program, State University of New York, Brooklyn, NY, USA;6. Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica;7. Caribbean Institute for Health Research, University of the West Indies, Mona, Kingston, Jamaica;8. Department of Surgery, Radiology, Anaesthesia and Intensive Care, Section of Surgery, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica;9. Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Durham, NC, USA;10. Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA;11. Department of Epidemiology and Biostatistics, College of Public Health, Temple University, Philadelphia, PA, USA;1. Research Center of Virology and Biotechnology, Vector, Koltsovo 630559, Novosibirsk region, Russia;2. Institute of Molecular Biology and Biophysics, 630117 Novosibirsk, Russia;3. Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, Russia;4. National Research Tomsk State University, 634050 Tomsk, Russia;5. Institutе of Internal and Preventive Medicine, Branch of ICIG SB RAS, 630089 Novosibirsk, Russia |
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| Abstract: | ![]()
BackgroundEuropean (E) variants of HPV 16 are evenly distributed among world regions, meanwhile Non-European variants such as European-Asian (EAs), Asian American (AA) and African (Af) are mostly confined to Eastern Asia, The Americas and African regions respectively. Several studies have shown that genetic variation of HPV 16 is associated with the risk of cervical cancer, which also seems to be dependent on the population. This relationship between ethnicity and variants have led to the suggestion that there is co-evolution of variants with humankind. Our aim was to evaluate the relationship between the individual ancestry proportion and infection with HPV 16 variants in cervical cancer.MethodsWe examined the association between ancestry and HPV 16 variants in samples of 82 cervical cancer cases from different regions of Colombia. Individual ancestry proportions (European, African and Native American) were estimated by genotyping 106 ancestry informative markers. Variants were identified by PCR amplification of the E6 gene, followed by reverse line blot hybridization (RLB) with variants specific probes.ResultsOverall European (E) and Asian American (AA) variants frequency was 66.5% and 33.5% respectively. Similar distribution was observed in cases with higher proportions of European or African ancestry. A higher Native American ancestry was significantly associated with higher frequency of E variants (median ancestry > 23.6%, Age and place of birth adjusted OR: 3.55, 95% CI: 1.26–10.03, p = 0.01). Even further, an inverse geographic correlation between Native American ancestry and frequency of infections with AA variants was observed (ρ = −0.825, p = 0.008). Regions with higher proportion of Native American ancestry had a lower frequency of AA variants of HPV 16.ConclusionsThis study suggests replacement of AA variants by E variants of human papillomavirus 16 in cervical cancer cases with high Native American ancestry. |
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| Keywords: | Human papillomavirus 16 HPV variants Genetic ancestry Cervical cancer Admixture Colombia |
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