The intracarotid etomidate Wada test: A 54-patient series |
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| Institution: | 1. State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Mathematics and Physics, Xinjiang Agricultural University, Urumqi 830052, China;1. Department of Radiology and Oncology, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil;2. LIM44-Laboratory of Magnetic Resonance in Neuroimaging, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil;3. Department of Neurology, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, Brazil;1. School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea;2. School of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea;3. Department of Materials Science and Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA;4. Institute of Physics and Applied Physics, Yonsei University, Seoul 03722, Republic of Korea;1. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China;2. Department of Radiotherapy, Beijing Geriatric Hospital, Beijing 100095, China;3. Center of Neurosurgery, PLA NAVY General Hospital, Beijing 100037, China |
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| Abstract: | Hemispheric language dominance and isolated hemispheric memory function evaluation can be undertaken with the intracarotid injection of a general anesthetic agent (Wada test). Amobarbital has been traditionally used as the anesthetic agent, but legal and commercial constraints limit its use. We evaluated the use of etomidate as an alternative agent for the Wada test in a series of 54 consecutive adult patients with mesial temporal sclerosis undergoing presurgical evaluation for epilepsy surgery. Language lateralization and hemispheric memory function evaluation were successfully achieved in all cases. Side effects (somnolence, tremor, and dystonia) were infrequent, minor, and transient and did not require interruption of the procedure. Etomidate appears to be a safe and effective alternative agent to amobarbital in the Wada test. Similarly to the amobarbital Wada test, the ability of the etomidate Wada test to predict postoperative memory decline remains unclear. |
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