Role of translation initiation factor 4G in lifespan regulation and age-related health |
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| Affiliation: | 1. Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, México, D.F., Mexico;2. Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México UNAM, México, D.F., Mexico;3. Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México UNAM, México, D.F., Mexico;1. Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, The Netherlands;2. Liver Clinic University Health Network, Division of Gastroenterology, University of Toronto, Canada;3. Structural Biology Unit, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain;4. Department of Biochemistry and Molecular and Cell Biology and Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Unit IQFR, Consejo Superior de Investigaciones Científicas-BIFI, Universidad de Zaragoza, Spain, and Fundacion ARAID, 500018 Government of Aragon, Spain;5. Institute for Research in Biomedicine, 08028 Barcelona, Spain;1. Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India;2. Academy of Scientific and Innovative Research (AcSIR), Rafi Marg, New Delhi, India;3. G.N.R. Knowledge Centre for Genome Informatics, Institute of Genomics and Integrative Biology, CSIR, New Delhi, India |
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| Abstract: | ![]()
Inhibiting expression of eukaryotic translation initiation factor 4G (eIF4G) arrests normal development but extends lifespan when suppressed during adulthood. In addition to reducing overall translation, inhibition alters the stoichiometry of mRNA translation in favor of genes important for responding to stress and against those associated with growth and reproduction in C. elegans. In humans, aberrant expression of eIF4G is associated with certain forms of cancer and neurodegeneration. Here we review what is known about the roles of eIF4G in molecular, cellular, and organismal contexts. Also discussed are the gaps in understanding of this factor, particularly with regard to the roles of specific forms of expression in individual tissues and the importance of understanding eIF4G for development of potential therapeutic applications. |
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| Keywords: | Ageing Protein synthesis eIF4G IFG-1 Translation initiation Longevity |
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