| 补骨脂素乳膏与凝胶体外释放与透皮吸收的比较研究 |
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| 引用本文： | 黄芳芳,杨得坡,梁淑明. 补骨脂素乳膏与凝胶体外释放与透皮吸收的比较研究[J]. 中成药, 2007, 29(3): 349-351 |
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| 作者姓名： | 黄芳芳 杨得坡 梁淑明 |
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| 作者单位： | 中山大学药学院生药学与天然药物化学实验室,广东,广州,510080 |
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| 基金项目： | 广东省中医药管理局资助项目 |
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| 摘 要： | 目的:比较2种补骨脂素乳膏与补骨脂凝胶体外释放和透皮吸收的特点。方法:分别采用溶出试验仪和Franz扩散池法进行体外释放和透皮吸收实验,并用高效液相色谱法测定释放液、接收液和皮肤中补骨脂素的含量。结果:三种制剂的体外释放和体外透皮均符合零级动力学方程,2种乳膏释放速率无差别;皮肤中补骨脂素的滞留量无显著性差异。结论:补骨脂素凝胶的体外透皮效果优于乳膏。
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| 关 键 词： | 补骨脂素 乳膏 凝胶 体外释放 透皮吸收 |
| 文章编号： | 1001-1528（2007）03-0349-03 |
| 修稿时间： | 2006-02-22 |
Comparison of the release and percutaneous penetration in vitro between psoralen ointment and gel |
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| HUANG Fang-fang,YANG De-po,LIANG Shu-ming. Comparison of the release and percutaneous penetration in vitro between psoralen ointment and gel[J]. Chinese Traditional Patent Medicine, 2007, 29(3): 349-351 |
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| Authors: | HUANG Fang-fang YANG De-po LIANG Shu-ming |
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| Affiliation: | Lab of Pharmacognosy and Natural Medicinal Chemistry , School of Pharmaceutical Sciences, Sun Yat-sen University, Gnangzhou 510080, China |
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| Abstract: | AIM: To compare the release and percutaneous penetration in vitro among 2 kinds of the psoralen ointments and its gel. METHODS: Dissolution tester and Franz diffusion cells were adopted as the release and percutaneous penetration in vitro, and HPLC was used to measure the amount of psoralen in the releasing solution, receiving solution and the skin. RESULTS: The release and percutaneous penetration of psoralen from the 3 kinds of preparation conformed to the zero kinetic equation. The steady-state penetration rate of psoralen in the gel was higher than that of the ointment, and there was no significant difference between 2 kinds of ointments. CONCLUSION: Gel is a better choice for percutaneous penetration of psoralen. |
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| Keywords: | psoralen ointment gel in vitro release percutaneous penetration |
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