老年冠心病患者血清脂质和脂质过氧化物测定的临床意义

本文观测了４４例老年冠心病患者血清脂质，丙二醛和超氧化物歧化酶，并与健康老年人对照比较，结果显示除胆固醇外其余各项指标２组间均有显著差异，老年ＣＨＤ组ＭＤＡ明显高于对照组，而ＳＯＤ则与之相反。多元回归分析表明，血清低密度脂蛋白胆固醇，而血清高密度脂蛋白胆固醇与ＳＯＤ呈显著正相关。提示老年ＣＨＤ患者高脂血症与脂质过氧化间有一定关系，它对判断老年ＣＨＤ的病情及预后有重要参考意义。

Clinical significance of serum lipid and lipid peroxidase determination in coronary artery disease of the aged

The levels of serum lipoprotein (a ) [LP (a)],apolipoprotein A1 (ApoA1), apolipoprotein B (Apo B), high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG), malondialdehyde (MDA) and superoxide dismutase (SOD)were measured in 30 healthy old subjects and 44 old patients with coronary heart disease(CHD). Our results showed that the LP (a), ApoB, LDL-C and MDA were higher and ApoA1, HDL-C and SOD were lower in CHD patients than in controls (ApoB, P<0.05;others,P<0.01 ). Multiple regressive analysis revealed that levels of LDL-C correlated significantly with level of MDA (r=0.5139, P<0.001) and level of HDL-C correlated significantly with serum SOD activity (r=0.5702,P<0.001). The results suggested that hyperlipemia in old CHD patients were closely related to lipids peroxidation. This point may be useful in the assessment of the patients condition and the prognosis.