多西他赛联合卡铂治疗乳腺癌疗效分析

目的：探讨多西他赛联合卡铂治疗乳腺癌的效果以及毒副作用。方法随机抽取2008～2010年度河南科技大学第一附属医院乳腺外科收治并用多西他赛联合卡铂化疗的60例乳腺癌患者,对本实验组所选患者的临床资料进行回顾性分析。结果所选60例患者,其中7例症状完全缓解,29例部分缓解,17例病情稳定,6例肿瘤复发或者发生远处转移,总有效率90％。所有患者均随访3 a,转移或复发时间平均为36个月,转移最多的部位是肝和肺。本实验组选中的60例患者,脱发者35例,白细胞下降者32例,贫血患者9例。在整个化疗过程中仅有2例患者不能耐受而调整化疗方案。无患者因心脏或肾脏毒性不能耐受化疗而调整方案。结论多西他赛联合奥沙利铂治疗乳腺癌效果显著,且毒副反应小,减轻了患者化疗过程中的痛苦,有在临床普遍开展的价值。

Efficacy Analysis on Docetaxel and Carboplatin in Treatment of Breast Cancer

Objective To investigate docetaxel and carboplatin treatment effects and side effects of breast cancer. Methods The 60 cases of breast cancer randomly treated breast surgery in Henan University of Science and Technology since 2008 ~201 0 with docetaxel and carboplatin chemotherapy,clinical information on the patients in the experimental group were retrospectively analyzed.Selected. Results Of 60 patients, including seven cases of complete remission of symptoms,29 cases of the disease in some patients remission, stable disease in 1 7 patients,6 patients with tumor recurrence or distant metastasis.The total effective rate was 95%.All patients were followed up for three years,metastatic or recurrent average of 36 months,the largest site of metastatic sites are liver metastases and lung metastases.The experimental group selected 60 patients,35 cases of hair loss,there were 32 cases of leukopenia,anemia patients,9 patients.Only 2 patients who could not tolerate chemotherapy adjustments throughout the course of chemotherapy.No patients with cardiac or renal toxicity could not tolerate chemotherapy and adjustment programs. Conclusion Docetaxel and oxaliplatin treatment of breast cancer is remarkable ,and the toxic side effects,reduce the pain of patients during chemotherapy,they are generally carried out with the clinical value.