| 密蒙花方抑制缺氧状态下人血管内皮细胞增殖及其VEGF信号转导机制研究 |
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| 引用本文： | 吴正正,严京,接传红,高健生,陈皆春. 密蒙花方抑制缺氧状态下人血管内皮细胞增殖及其VEGF信号转导机制研究[J]. 中国中医眼科杂志, 2011, 21(5): 249-252 |
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| 作者姓名： | 吴正正 严京 接传红 高健生 陈皆春 |
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| 作者单位： | 中国中医科学院眼科医院,北京,100040 |
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| 基金项目： | 国家自然科学基金(项目编号:30772825) |
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| 摘 要： |
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| 关 键 词： | 密蒙花方 内皮细胞 缺氧 血管内皮生长因子 信号转导 |
Study on the mechanism of Mimeng Flower Decoction on VEGF signal transmission and inhibition of human umbilical vascular endothelial cells induced by chronic hypoxia |
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| WU Zhengzheng,YAN Jing,JIE Chuanhong,et al.. Study on the mechanism of Mimeng Flower Decoction on VEGF signal transmission and inhibition of human umbilical vascular endothelial cells induced by chronic hypoxia[J]. Journal of Traditional Chinese Ophthalmology, 2011, 21(5): 249-252 |
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| Authors: | WU Zhengzheng YAN Jing JIE Chuanhong et al. |
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| Affiliation: | WU Zhengzheng,YAN Jing,JIE Chuanhong,et al.Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China |
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| Abstract: | OBJECTIVE To study the mechanism of Mimeng Flower Decoction on VEGF signal transmission to inhibit the proliferation of human umbilical vascular endothelial cells(HUVEC) induced by chronic hypoxia.METHODS HUVEC were cultured in vitro.Used CoCl2 to set up the cell chemistry hypoxia model,in the same time,10,20,40mg/ml Mimeng Flower Decoction extract was added to the HUVEC separately,the following studies were made after incubation of 24h.Through RT-PCR method,detected the mRNA phosphorylation expression leve... |
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| Keywords: | Mimeng Flower Decoction endothelial cell hypoxia vascular endothelial growth factor(VEGF) signal transduction |
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