Strong association between an HLA-DR antigen and thyroid carcinoma |
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| Authors: | NICOLA PANZA LUIGI DEL VECCHIO MICHELE MAIO MARIO De FELICE GAETANO LOMBARDI MARCO MINOZZI SERAFINO ZAPPACOSTA |
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| Affiliation: | Istituto di Endocrinologial and Cattedra di Immunologia, c/o Instituto di Patologia Generale, Naples, Italy;Seconda Facoltàdi Medicina e Chirurgia, Universitàdi Napoli, Naples, Italy |
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| Abstract: | ![]()
A group of 20 patients affected with thyroid carcinoma, all from Southern Italy, was typed for HLA-A,-B,-C and -DR antigens. Sixteen of them (80%) typed for DR1, while in the control group (120 unrelated healthy individuals from the same region) only 22 (18.3%) shared the same antigen ( x 22 = 32.96). The data indicate a highly significant association between the HLA-DR1 gene and the thyroid carcinoma. |
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