肥胖、瘦素与多囊卵巢综合征

为探讨肥胖、瘦 素（ｌｅｐｔｉｎ） 与多囊卵巢综合征（ Ｐ Ｃ Ｏ Ｓ）的关系，本研究观察 ４０ 例 Ｐ Ｃ Ｏ Ｓ 患者体重指数（ Ｂ Ｍ Ｉ）、腰围／臂围比值（ Ｗ Ｈ Ｒ）、血 ｌｅｐｔｉｎ 水平，其与血性激素和口服糖耐量试验（ Ｏ Ｇ Ｔ Ｔ）中胰岛素（ Ｉｎｓ）浓度的关系，并与 １６ 例正常妇女进行对照。结果显示， Ｐ Ｃ Ｏ Ｓ患者有高雄激素高胰岛素血症， Ｗ Ｈ Ｒ 和血 ｌｅｐｔｉｎ 浓度升高，我们认为肥胖和 ｌｅｐｔｉｎ 水平的升高与 Ｐ Ｃ Ｏ Ｓ密切相关。

Relationship between obesity, blood leptin and polycystic ovarian syndrome

Objective: To study the relationship between obesity, blood leptin and polycystic ovarian syndrome (PCOS). Methods: Body mass index (BMI), waist to hip ratio (WHR), serum leptin, luteinizing hormne, follicle stimulating hormone, estradiol, testosterone (T), C peptide, insulin concentration during oral glucose tolerance test were assessed in 40 PCOS patients and 16 normal women. Result: The PCOS patients showed high levels of T and insulin, and the WHR, serum leptin concentration were also high. Conclusion: Obesity and high leptin concentration are closely related to PCOS.