抗癌药物马蔺子素的β-环糊精包络物研究

目的研究抗癌药物马蔺子素与β-环糊精的主-客体包络行为。方法在悬汞电极上用循环伏安法考察β-环糊精不存在和存在时马蔺子素还原波的变化。结果在0.04 mol·L^-1 KH₂PO₄-Na₂HPO₄ (pH 6.8)近生理介质中,β-环糊精的引入使马蔺子素的还原波峰电流降低,峰电位正移。结论电活性客体分子马蔺子素与主体分子β-环糊精生成1∶1的包络物。用“电流法”测得其形成常数K_f值为1.92×10³ L·mol^-1。包络物的生成增强了马蔺子素的稳定性。

STUDY ON THE INCLUSION COMPLEX OF IRISQUINONE WITH β-CYCLODEXTRIN

AIMTo study the host-guest inclusion behavior of anticancer drug irisquinone with β-cyclodextrin. METHODSThe variance of the reduction ware of irisquinone in the absence and presence of β-cyclodextrin was examined by cyclic voltammetry at the hanging mercury drop electrode. RESULTSIn 0.04 mol·L^-1 KH₂PO₄-Na₂HPO₄ (pH 6.8) supporting electrolyte which was close to physiological condition, the introduction of β-cyclodextrin resulted in both decrease of reduction current and the positive shift of peak potential of reduction ware of irisquinone. CONCLUSIONThe electroactive guest molecule irisquinone was complexed with host molecule β-cyclodextrin to the formation of 1∶1 inclusion complex. The inclusion constant K_f was 1.92×10³ L·mol^-1 by the electric current method. The formation of the inclusion complex enhanced the stability of irisquinone.