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| 自体虹膜色素上皮细胞移植治疗视网膜色素上皮细胞变性研究 | |
| 引用本文： | 徐国兴,谢茂松,郭健,郑卫东,何青,林鸿,高珊. 自体虹膜色素上皮细胞移植治疗视网膜色素上皮细胞变性研究[J]. 国际眼科杂志, 2008, 8(3): 538-539 |
| 作者姓名： | 徐国兴 谢茂松 郭健 郑卫东 何青 林鸿 高珊 |
| 作者单位： | 福建医科大学附属第一医院福建省眼科研究所,中国福建省福州市,350005 |
| 基金项目： | 中国福建省重大科研课题基金(No.2002Y002)~~ |
| 摘 要： | 目的:研究自体虹膜色素上皮细胞(iris pigment epithelium,IPE)移植治疗视网膜色素上皮细胞变性的效果。方法:采用酶-机械分离-酶消化法获取高纯度、高活力的IPE细胞用于移植,采用外路法将IPE细胞悬液移植入视网膜下腔。结果:IPE移植术后患者眼底移植区色素沉着减少,未见渗出,出血,视网膜平,视力入院时的0.15,术后2wk提高至0.2。多焦ERG显示移植区P1波平均反应密度上升。结论:自体虹膜色素上皮细胞移植有望成为视网膜色素上皮细胞变性疾病治疗的一新方法。 |
| 关 键 词： | 视网膜色素上皮变性 治疗 虹膜色素上皮 移植 |
| 修稿时间： | 2007-12-23 |
Iris pigment epithelium transplantation for treating retinitis pigmentasa |
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| Guo-Xing Xu,Mao-Song Xie,Jian Guo,Wei-Dong Zheng,Qing He,Hong Lin,Shan Gao. Iris pigment epithelium transplantation for treating retinitis pigmentasa[J]. International Eye Science, 2008, 8(3): 538-539 | |
| Authors: | Guo-Xing Xu Mao-Song Xie Jian Guo Wei-Dong Zheng Qing He Hong Lin Shan Gao |
| Affiliation: | Ophthalmology Research Institution of Fujian Province,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian Province,China |
| Abstract: | AIM:To investigate the effect of the iris pigment epithelium(IPE)transplantation for treating retinitis pigmentasa(RP).· METHODS:RPE with high purity and activity was obtained from enzyme-mechanical separation-enzyme digestion method,and then was transplanted to the subretinal space by extraocular surgery.· RESULTS:After operation,chromatosis at transplantation region of fundus decreased,without effusion or hemorrhage.Retina was flat,and the visual acuity was improved to 0.2 at two weeks after operation compared with 0.15 when was admitted to hospital.P1 wave reaction density was increased from multi-focus ERG.· CONCLUSION:IPE cells transplantation may be a new method in treating RP. |
| Keywords: | retinitis pigmentasa treat iris pigment epithelium transplantation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |