AD患儿外周血白细胞介素-17、白细胞介素-8、血清IgE及EOS水平变化及其意义

目的 探讨特应性皮炎(AD)患儿外周血白细胞介素-17(IL-17)、白细胞介素-8(IL-8)、免疫球蛋白E(IgE)及嗜酸性粒细胞计数(EOS)的水平变化及其意义.方法 选取120例AD患儿作为AD组,以同期30名健康儿童作为对照组,检测并比较两组外周血IL-17、IL-8、IgE及EOS的水平,依据皮损严重程度对AD患儿进行分层分析.结果 AD组患儿的外周血中IL-17、IL-8、IgE及EOS水平均显著高于对照组(P＜0.05);AD组患儿的外周血中IL-17、IL-8、IgE、EOS水平及AD严重程度评分各亚组间比较,重度组＞中度组＞轻度组,且差异具有统计学意义(P＜0.05);AD组患儿的外周血中IL-17、IL-8、IgE、EOS水平与AD严重程度评分均呈显著正相关(P＜0.05).结论 AD儿童外周血IL-17、IL-8、IgE及EOS水平均显著的增高,且与病情严重程度密切相关.

Changes of serum-17, interleukin-8, serum IgE and EOS levels in children with AD and their clinical significance

Objective To investigate the changes and significance of IL-17,IL-8,serum IgE and EOS levels in peripheral blood of children with AD.Methods Selected the Zhengzhou Children's Hospital in January 2011 ～ December 2015 outpatient diagnosis and treatment of 120 patients with AD children (AD group),over the same period 40 cases of healthy children as a control group,the levels of EOS,IL-8,IgE and IL-17 in peripheral blood of two groups were detected and compared,according to the severity of skin lesions in children with AD stratified analysis.Results The peripheral blood of AD patients IL-17,IL-8,IgE and EOS levels were significantly higher than the control group and there were statistical significantly differences (P＜0.05).IL-17,IL-8,IgE,EOS levels and AD severity score in the peripheral blood of AD group were compared among the subgroups,the severe group ＞ moderate group ＞ mild group and there were statistical significantly differences (P＜0.05).The levels of,IL-17,IL-8,IgE and EOS were significantly positively correlated with the AD severity scores (P＜0.05) in the peripheral blood of children with AD.Conclusion IL-17,IL-8,IgE and EOS levels were significantly higher in AD children,and it is closely related to the pathogenesis and severity of the disease.