支气管哮喘与气道反应性之间相互关系的分析

目的评价气道反应性对支气管哮喘发病的影响，探讨哮喘的病因。方法在三个县的范围内，依据哮喘患者作为指示病例确定了６４１个哮喘核心家系，对哮喘家系中的每位成员逐一询问调查，同时测定每位成员的气道反应性。用ＥＰＩ５．０１程序软件处理分析资料，计算优势比（ＯＲ）来评价气道反应性与哮喘之间的关系。结果７２％有哮喘史者气道反应测定为阳性，气道高反应性者仅有７０％的人患过哮喘；哮喘家系中气道反应阳性的亲属患哮喘的危险性显著增加，是气道反应阴性亲属的５．８倍（Ｐ＜０．０１）。结论气道高反应性是哮喘的重要危险因素之一

A study of the correlations between asthma and airway responsiveness

Objective To evaluate the effect of airway responsiveness on asthma and to study the causes of asthma. Methods The 641 nuclear families were confirmed by indicator cases with asthma in three counties. Investigation and methacholine challenge test were conducted for all relatives of the nuclear families. The data were by EPI5.01 and the odds ratio ( OR )was employed to evaluate the correlation between asthma and airway responsiveness. Results 72 percent of persons with asthmas history showed airway hyperresponsiveness, but only 70 per cent of persons with airway hyperresponsiveness suffered asthma. The risk for asthma in relatives with positive airway responsiveness was 5.8 times higher than those with negative airway responsiveness ( P >0.01) among the nuclear families. Conclusion Airway hyperresponsiveness is one of the risk factors of asthma.