维持性腹膜透析患者腹膜透析相关性葡萄球菌腹膜炎的发生率及危险因素分析

目的 探讨维持性腹膜透析患者腹膜透析相关性葡萄球菌腹膜炎的发生率及相关危险因素.方法 以中山大学附属东华医院腹膜透析中心192例患者为研究对象.根据腹膜透析液培养结果分成腹膜炎组与正常组.采用多因素logistic回归分析腹膜透析相关性葡萄球菌腹膜炎的危险因素.结果 共16例（8.3％）患者发生腹膜透析相关性葡萄球菌腹膜炎.致病菌以表皮葡萄球菌为主,占50.0％（8/16）.治愈12例（75.0％）,死亡1例.高龄（OR=1.35,95％ CI 1.16～7.68,P=0.026）、糖尿病（OR =3.34,95％ CI 1.90～6.54,P＜0.001）、低血红蛋白（OR=1.68,95％ CI 1.21～6.48,P=0.022）及低白蛋白血症（OR=1.04,95％ CI1.02～1.07,P=0.036）是腹膜透析相关性葡萄球菌腹膜炎的相关危险因素.结论 腹膜透析相关性葡萄球菌腹膜炎发生率较高;高龄、低血红蛋白、糖尿病及低白蛋白血症是其相关危险因素.

The prevalence and associated factors of peritoneal dialysis-related staphylococcus peritonitis

Objective To study the prevalence and associated factors of peritoneal dialysis-related staphylococcus peritonitis in continuous ambulatory peritoneal dialysis （CAPD） patients.Methods One hundred and ninty-two CAPD cases with peritoneal dialysis-related peritonitis in our peritoneal dialysis （PD） centers were retrospectively analyzed.The associated factors of peritoneal dialysis-related staphylococcus peritonitis were investigated through Logistic regression analysis.Results The prevalence of peritoneal dialysis-related staphylococcus peritonitis was 16（8.3％）.The major strain was staphylococcus spidermidis （50.0％,8/16）,and the cure rate was 75.0％ （12/16）.One case died.Among those with peritoneal dialysis-related staphylococcus peritonitis,older age （OR =1.35,95％ CI 1.16-7.68,P =0.026）,diabetes （OR =3.34,95％ CI 1.90-6.54,P ＜ 0.001）,lower hemoglobin （OR =1.68,95％ CI 1.21-6.48,P =0.022） and lower albumin （OR =1.04,95％ CI 1.02-1.07,P =0.036） were independently associated with increased risk of peritoneal dialysis-related staphylococcus peritonitis.Conclusions Staphylococcus epidermidis peritonitis has higher incidence rate in CAPD patients.Older age,diabetes,lower hemoglobin and lower albumin are independently associated with increased risk of peritoneal dialysisrelated staphylococcus peritonitis.