Analysis of the renal tissue of a woman chronically exposed to cadmium |
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Authors: | M Cikrt J Hurych D Kuklová J Havrdová P Lep?í J Kopecký B Milek A Nau? |
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Institution: | (1) Centre of Industrial Hygiene and Occupational Diseases, Institute of Hygiene and Epidemiology, robárova 48, 100 42 Prague;(2) Clinic of Occupational Medicine, Medical Faculty of Hygiene, robárova 50, 100 00 Prague;(3) Hygienic Centre of Prague, Rytíská 12, 110 00 Prague, Czechoslovakia |
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Abstract: | Summary In a 61-year-old woman, who had been exposed for 20 years to cadmium in the production of Ni-Cd batteries, nephrectomy of the contracted kidney was performed. The removed kidney was examined histologically and the cadmium concentration was determined in the cortex (44.97 g g–1) and in the medulla (7.71 g g–1). The homogenates of the renal cortex and medulla were subjected to gel filtration on Sephadex G-75. In the cortex, as well as the medulla, cadmium was predominantly found in the low-molecular (metallothionein) fraction, but in the cortex, Cd content in this fraction was six times higher than in the medulla. The determination of SH groups and proteins in high- and low-molecular fractions indicates an induction of the metallothionein formation primarily in the renal cortex. |
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Keywords: | Cadmium Kidney Metallothionein Occupational exposure |
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