| 乐肝复方合剂对体外培养大鼠肝细胞的保护作用 |
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| 引用本文： | 蔡英兰,朴丽花,全贵红,崔春爱,李相伍,金东洙. 乐肝复方合剂对体外培养大鼠肝细胞的保护作用[J]. 延边医学院学报, 2008, 31(4) |
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| 作者姓名： | 蔡英兰 朴丽花 全贵红 崔春爱 李相伍 金东洙 |
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| 作者单位： | 延边大学基础医学院解剖学与组织胚胎学教研部 |
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| 摘 要： | [目的]探讨乐肝复方合剂对四氯化碳损伤体外培养大鼠肝细胞的保护作用.[方法]体外培养大鼠肝细胞,用四氯化碳处理制作肝细胞损伤模型,观察乐肝复方合剂对损伤肝细胞内琥珀酸脱氢酶(SDH)、酸性磷酸酶(ACPase)、葡萄糖-6-磷酸酶(G-6-Pase)活性及糖原含量的影响.[结果]乐肝复方合剂可显著提高损伤肝细胞内SDH,G-6-Pase活性,提高糖原含量,抑制ACPase活性.[结论]乐肝复方合剂对四氯化碳损伤体外培养大鼠肝细胞具有保护作用.
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| 关 键 词： | 肝疾病 植物,药用 大鼠 |
Protective effects of the Legan compound on cultured hepatocytes of rats in vitro |
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| CAI Ying-lan,PIAO Li-hua,QUAN Gui-hong,CUI Chun-ai,LI Xiang-wu,JIN Dong-zhu. Protective effects of the Legan compound on cultured hepatocytes of rats in vitro[J]. Journal of Medical Science Yanbian University, 2008, 31(4) |
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| Authors: | CAI Ying-lan PIAO Li-hua QUAN Gui-hong CUI Chun-ai LI Xiang-wu JIN Dong-zhu |
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| Abstract: | OBJECTIVE To investigate the protective effects of the Legan compound on CCl_4-intoxicated primary cultured hepatocytes of rats in vitro.METHODS The hepatocytes of rats were cultured in vitro, and made hepatocytes injury models by CCl_4,and the effects of the Legan compound for the activity of SDH,ACPase,G-6-Pase activeties and amount of hepatic glycogen were observed.RESULTS The Legan compound increased the activity of SDH,G-6-Pase and the amount of hepatic glycogen,and restrain the activety of ACPase.CONCLUSION The Legan compound has protective effects on CCl_4-induced injury of primary cultured hepatocytes of rats in vitro. |
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| Keywords: | liver diseases plants medicinal rats |
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