| 钩藤总碱缓释滴丸的热稳定性实验 |
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| 引用本文： | 张兆芹,杨雪萍,刘卫.钩藤总碱缓释滴丸的热稳定性实验[J].实用医药杂志(山东),2011,28(8). |
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| 作者姓名： | 张兆芹 杨雪萍 刘卫 |
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| 作者单位： | 88医院药剂科,山东泰安,271000 |
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| 基金项目： | 山东省科技发展计划项目 |
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| 摘 要： | 目的研究钩藤总碱缓释滴丸中钩藤总碱、钩藤碱、异钩藤碱的热稳定性。方法钩藤总碱缓释滴丸在25、40、60℃下分别放置90、180、270 d,酸碱滴定法测定钩藤总碱含量,高效液相法测定钩藤碱及异钩藤碱的含量。结果钩藤总碱和钩藤碱在25、40、60℃下270 d内无明显降解,异钩藤碱在40℃第180天检测时出现含量明显降低(P<0.05),60℃时第90天出现明显降低。结论钩藤总碱缓释滴丸在常温下稳定,但在较高温度下可致主要有效成分含量降低。
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| 关 键 词： | 钩藤总碱 缓释滴丸 钩藤碱 异钩藤碱 |
Thermal stability experiment of Rhynchophyllae total alkali sustained-release dropping pills ZHANG |
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| Zhao-qin,YANG Xue-ping,LIU Wei.Thermal stability experiment of Rhynchophyllae total alkali sustained-release dropping pills ZHANG[J].Practical Journal of Medicine & Pharmacy,2011,28(8). |
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| Authors: | Zhao-qin YANG Xue-ping LIU Wei |
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| Abstract: | Objective Study on the thermal stability of Rhynchophyllae total alkali,Rhynchophylline and Isorhynchophylline in sustained-release dropping pills.Methods Rhynchophyllae total alkali sustained-release dropping pills were put in 25,40,60 ℃ surrounding for 90,180,270 days.The content of Rhynchophyllae total alkali was measured by acid-base titrations,Rhynchophylline and Isorhynchophylline was measured by HPLC.Results The content of Rhynchophyllae total alkali and Rhynchophylline had no significant change in 25,40,60 ℃ surrounding for 270 days.The content of Isorhynchophylline decreased significantly in 40℃ for 180 days(P<0.05),and in 60 ℃for 90 days,respectively.Conclusion Rhynchophyllae total alkali sustained-release dropping pills are stability in room temperature,but Isorhynchophylline can be decomposed in high temperature. |
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| Keywords: | Rhynchophyllae total alkali Sustained-release dropping pills Rhynchophylline Isorhynchophylline |
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