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| 不同炮制方法对关木通减毒存效作用的比较 | |
| 引用本文： | 张春红,曹蕊,李虔全,张娜,张连学,李旻辉.不同炮制方法对关木通减毒存效作用的比较[J].中国实验方剂学杂志,2012,18(10):149-152. |
| 作者姓名： | 张春红 曹蕊 李虔全 张娜 张连学 李旻辉 |
| 作者单位： | 1. 内蒙古科技大学包头医学院,内蒙古包头014060;吉林农业大学中药材学院,长春130118 2. 吉林农业大学中药材学院,长春,130118 3. 内蒙古科技大学包头医学院,内蒙古包头,014060 |
| 基金项目： | 吉林农业大学博士启动基金项目(2007011) |
| 摘 要： | 目的:比较各种炮制方法对关木通减毒存效作用,选择最佳的关木通炮制方法。方法:以关木通生品及各炮制品中马兜铃酸A、齐墩果酸及常春藤皂苷元含量为指标,比较了5种炮制方法(醋炙、蜜炙、姜炙、碱制、盐炙)减毒存效效果。结果:生品、醋炙品、蜜炙品、姜炙品、碱制品、盐炙品中马兜铃酸A含量分别为0.27%,0.13%,0.15%,0.20%,0.14%,0.18%;齐墩果酸含量分别为0.21%,0.15%,0.20%,0.13%,0.01%,0.01%;常春藤皂苷元含量分别为0.11%,0.08%,0.09%,0.07%,0.01%,0.01%。结论:关木通最佳减毒存效炮制方法为蜜炙法。 |
| 关 键 词： | 炮制 关木通 减毒存效 |
| 收稿时间： | 2011/11/28 0:00:00 |
Study on Toxicity Attenuation and Efficacy Reservation of Manchurian Dutchmanspipe Stem Following Different Processing Methods |
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| ZHANG Chun-hong,CHAO Rui,LI Qian-quan,ZHANG N,ZHANG Lian-xue and LI Ming-hui.Study on Toxicity Attenuation and Efficacy Reservation of Manchurian Dutchmanspipe Stem Following Different Processing Methods[J].China Journal of Experimental Traditional Medical Formulae,2012,18(10):149-152. | |
| Authors: | ZHANG Chun-hong CHAO Rui LI Qian-quan ZHANG N ZHANG Lian-xue and LI Ming-hui |
| Institution: | Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014060, China;Academy of Chinese Traditional Medicine, Jilin Agricultural University, Changchun 130118,China;Academy of Chinese Traditional Medicine, Jilin Agricultural University, Changchun 130118,China;Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014060, China;Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014060, China;Academy of Chinese Traditional Medicine, Jilin Agricultural University, Changchun 130118,China;Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014060, China |
| Abstract: | Objective: Study on toxicity attenuation and efficacy reservation of Manchurian Dutchmanspipe Stem following five different processing methods, and to collect best processing methods. Method: Five methods of processing herbs with vinegar, honey, ginger, alkali and salt were compared focusing on the optimal toxicity attenuation effect with content of aristolochic acid, hederagenin and oleanolic acid (OA) from Manchurian Dutchmanspipe Stem as evaluated index detected by RP-HPLC. Result: Content of aristolochic acid in raw herbs and the herbs processed with vinegar, honey, ginger, alkali and salt was as follows: 0.27%, 0.12%, 0.15%, 0.20%, 0.14%, 0.18%; content of oleanolic acid (OA) in raw herbs and the herbs processed with vinegar, honey, ginger, alkali and salt was: 0.21%, 0.15%, 0.20%, 0.13%, 0.01%, 0.01%; content of hederagenin in raw herbs and the herbs processed with vinegar, honey, ginger, alkali and salt was: 0.11%, 0.08%, 0.09%, 0.07%, 0.01%, 0.01% respectively. Conclusion: The honey processing was regarded as the optimal processing method for Manchurian Dutchmanspipe Stem. |
| Keywords: | processing Manchurian Dutchmanspipe Stem toxicity attenuation and efficacy reservation |
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