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| Liver histology in ICU patients dying from sepsis：A clinico-pathological study | |
| 作者姓名： | Koskinas J Gomatos IP Tiniakos DG Memos N Boutsikou M Garatzioti A Archimandritis A Betrosian A |
| 作者单位： | 2nd Department of Internal Medicine Athens Medical School,Athens 11527,Greece,Laboratory of Surgical Research,1st Department of Propaedeutic Surgery,Athens Medical School,Athens 11527,Greece,Laboratory of Histology and Embryology,Athens Medical School Athens 11527,Greece,Laboratory of Surgical Research,1st Department of Propaedeutic Surgery Athens Medical School Athens 11527,Greece,Laboratory of Surgical Research,1st Department of Propaedeutic Surgery Athens Medical School Athens 11527,Greece,Laboratory of Histology and Embryology,Athens Medical School Athens 11527,Greece,2nd Department of Internal Medicine,Athens Medical School,Athens 11527,Greece,Intensive Care Unit,Hippocration Hospital,Athens 11527,Greece |
| 摘 要： | AIM：To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit. METHODS： Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded. RESULTS： Liver biochemistries were increased in the majority of patients before death. Histology of liver biopsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholangitis/cholangiolitis in 20% of patients. Mixed hepatitic/ cholestatic type of liver injury was observed in 6/15 （40%） patients and hepatitc in 9/15 （60%）. Steatosis was observed in 11/15 （73.3%） patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was associated with increased hospitalization in the ICU prior death （P = 0.026）. CONCLUSION： Features of hepatitis and steatosis arethe main histological findings in the liver in the majority of patients dying from sepsis. |
| 关 键 词： | 败血症 肝脏组织学 活组织切片检查 临床研究 |
| 收稿时间： | 2007 Sep 18 |
Liver histology in ICU patients dying from sepsis: a clinico-pathological study |
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| Koskinas J,Gomatos IP,Tiniakos DG,Memos N,Boutsikou M,Garatzioti A,Archimandritis A,Betrosian A.Liver histology in ICU patients dying from sepsis: a clinico-pathological study[J].World Journal of Gastroenterology,2008,14(9):1389-1393. | |
| Authors: | Koskinas John Gomatos Ilias P Tiniakos Dina G Memos Nikolaos Boutsikou Maria Garatzioti Aspasia Archimandritis Athanasios Betrosian Alexander |
| Institution: | 1. 2nd Department of Internal Medicine,Athens Medical School,Athens 11527,Greece 2. Laboratory of Surgical Research,1st Department of Propaedeutic Surgery,Athens Medical School,Athens 11527,Greece 3. Laboratory of Histology and Embryology,Athens Medical School,Athens 11527,Greece 4. Intensive Care Unit,Hippocration Hospital,Athens 11527,Greece |
| Abstract: | AIM:To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit.METHODS:Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination.Liver function tests and clinical monitoring measurements were also recorded.RESULTS:Liver biochemistries were increased in the majority of patients before death.Histology of liver bi-opsy specimens showed portal inflammation in 73.3%,centrilobular necrosis in 80%,lobular inflammation in 66.7%,hepatocellular apoptosis in 66.6% and cholan-gitis/cholangiolitis in 20% of patients.Mixed hepatitic/cholestatic type of liver injury was observed in 6/15 (40%)patients and hepatitc in 9/15 (60%).Steatosis was ob-served in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma.Among the histological features,the presence of portal inflammation in liver biopsy was as-sociated with increased hospitalization in the ICU prior death (P = 0.026).CONCLUSION:Features of hepatitis and steatosis are the main histological findings in the liver in the majority of patients dying from sepsis. |
| Keywords: | Severe sepsis Liver Biopsy Histology |
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