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| 非布司他降解产物的LC-MS研究 | |
| 引用本文： | 冷柏榕, 严相平, 王康蕊, 王德才. 非布司他降解产物的LC-MS研究[J]. 中国现代应用药学, 2012, 29(3): 226-229. |
| 作者姓名： | 冷柏榕 严相平 王康蕊 王德才 |
| 作者单位： | 1.南京工业大学江苏省药物研究所，南京 210009;2南京工业大学药学院，南京 211816 |
| 摘 要： | 目的 研究非布司他的降解产物。方法 强制降解后以LC-MS测定，根据质谱测定结果结合结构及反应机制推测降解产物结构。结果 推测降解产物为2-[3-氰基-4-(2-异丁氧基)苯基]-4-甲基噻唑-5-羧酸甲酯、2-[3-氨基甲酰基-4(2-异丁氧基-)苯基]-4-甲基噻唑-5-羧酸、2-[3-氰基-4-(2-异丁氧基)苯基]-4-甲基-1-氧化噻唑-5-羧酸甲酯以及非布司他的二聚体。结论 该法为研究非布司他的稳定性及其可能的降解途径提供了参考。 |
| 关 键 词： | 非布司他 液相色谱-质谱 有关物质 降解产物 |
| 收稿时间： | 2011-08-01 |
| 修稿时间： | 2011-11-30 |
Study on Degradation Products of Febuxostat by LC-MS |
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| LENG Borong, YAN Xiangping, WANG Kangrui, WANG Decai. Study on Degradation Products of Febuxostat by LC-MS[J]. Chinese Journal of Modern Applied Pharmacy, 2012, 29(3): 226-229. | |
| Authors: | LENG Borong YAN Xiangping WANG Kangrui WANG Decai |
| Affiliation: | 1.Jiangsu Provincial Institute of Material Medica, Nanjing University of Technology, Nanjing 210009, China; 2.School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 211816, China |
| Abstract: | OBJECTIVE To investigate the degradation products of febuxostat. METHODS After forced degradation, products were determined by LC-MS. The structures of degradation products were elucidated by the results of mass spectrometry combined with the structure and the reaction mechanism. RESULTS It was speculated that the degradation products were 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylic acid methyl ester, 2-(3-carbamoyl-4-isobutoxyphenyl)-4- methylthiazole-5-carboxylic acid, 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-1-oxidation thiazole -5-carboxylic acid methyl ester, a dimmer of febuxostat. CONCLUSION The method provides a reference of studying the stability of febuxostat and possible degradation pathway. |
| Keywords: | febuxostat LC-MS related substance degradation product |
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